| Literature DB >> 20945837 |
Ling Zhou1, Chong Kiat Tan, Xiaojian Jiang, Feng Chen, Ying-Yeung Yeung.
Abstract
A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists.Entities:
Year: 2010 PMID： 20945837 DOI： 10.1021/ja1048972
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419