Literature DB >> 20944134

Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population.

Yu Qi1, Xin Li, Liang Zhao, John T Seykora.   

Abstract

BACKGROUND: Src-family tyrosine kinases (SFKs) play critical roles in regulating cellular differentiation and proliferation. Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation. The aim of this study was to determine whether Srcasm expression was altered in esophageal squamous epithelial carcinoma compared with normal epithelium in a Chinese population.
MATERIALS AND METHODS: We examined Srcasm immunohistochemical staining in 30 cases in both normal esophageal epithelium and esophageal squamous cell carcinoma (SCC) from the same patient in formalin-fixed paraffin embedded tissue blocks.
RESULTS: Srcasm protein expression levels are decreased in esophageal SCC compared to the esophageal normal epithelium.
CONCLUSION: This pattern of Srcasm expression suggests that it may act as a negative regulator in esophageal SCC cell signaling.

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Year:  2010        PMID： 20944134      PMCID： PMC3107990     

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  22 in total

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