| Literature DB >> 20943390 |
Andrew Scribner1, David Houck, Zhuhui Huang, Sarah Mosier, Michael Peel, Bernard Scorneaux.
Abstract
An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)<200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20943390 DOI： 10.1016/j.bmcl.2010.09.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823