Literature DB >> 20943267

Interferon-γ secretion by t(9;22) acute lymphoblastic leukemia-derived dendritic cells.

Michael T Brady1, Jaewoo Lee, Soldano Ferrone, Eunice S Wang, Meir Wetzler.   

Abstract

Interferon (IFN)-γ plays an important role in immunity and anti-tumor activity. It is produced by lymphocytes, but was recently shown to be also produced by human myeloid dendritic cells (DCs). We have shown that human mature t(9;22) acute lymphoblastic leukemia-derived (ALL) DCs induced autologous cytotoxic T cell responses and therefore asked whether t(9;22) ALL-DC secreted IFN-γ. IFN-γ varied among three cell line-derived ALL-DCs; median production from seven patient ALL-DCs was 3450 pg/ml (range 1450-8675). IFN-γ production was dependent on maturation of ALL-DCs. This is the first demonstration of IFN-γ production by t(9;22) ALL-DCs.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20943267      PMCID： PMC3021772          DOI： 10.1016/j.leukres.2010.09.003

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  8 in total

1.  T-Cell activation by t(9;22) acute lymphoblastic leukemia-derived dendritic-like cells is associated with increased tapasin expression.

Authors:  Jonathan A Claus; Michael T Brady; Jaewoo Lee; Kathleen A Donohue; Sheila N Sait; Soldano Ferrone; Meir Wetzler
Journal:  Cancer Immunol Immunother       Date:  2005-07-12       Impact factor: 6.968

2.  Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

Authors:  N J Stam; H Spits; H L Ploegh
Journal:  J Immunol       Date:  1986-10-01       Impact factor: 5.422

3.  Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells.

Authors:  David Vremec; Meredith O'Keeffe; Hubertus Hochrein; Martina Fuchsberger; Irina Caminschi; Mireille Lahoud; Ken Shortman
Journal:  Blood       Date:  2006-10-12       Impact factor: 22.113

Review 4.  Interferon-gamma is produced by another player of innate immune responses: the interferon-producing killer dendritic cell (IKDC).

Authors:  Mathieu Bonmort; Evelyn Ullrich; Grégoire Mignot; Bénédikt Jacobs; Nathalie Chaput; Laurence Zitvogel
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5.  HLA class II induction by interferon-gamma in K562 variant cell line: inhibition by serum lipid.

Authors:  S R Ress; J Rousseau; B Ratanjee; K Eidne; R P Millar; M Keraan
Journal:  Hum Immunol       Date:  1991-05       Impact factor: 2.850

6.  Characterization of dendritic-like cells derived from t(9;22) acute lymphoblastic leukemia blasts.

Authors:  Jaewoo Lee; Sheila N Sait; Meir Wetzler
Journal:  Int Immunol       Date:  2004-08-09       Impact factor: 4.823

7.  Beta 2-microglobulin-free HLA class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptide.

Authors:  Federico Perosa; Grazia Luccarelli; Marcella Prete; Elvira Favoino; Soldano Ferrone; Franco Dammacco
Journal:  J Immunol       Date:  2003-08-15       Impact factor: 5.422

8.  Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

Authors:  P Openshaw; E E Murphy; N A Hosken; V Maino; K Davis; K Murphy; A O'Garra
Journal:  J Exp Med       Date:  1995-11-01       Impact factor: 14.307
  8 in total
  3 in total

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Journal:  Blood Adv       Date:  2017-05-09

2.  The Expression of Interferon Gamma (IFN-γ) and Interleukin 6 (IL6) in Patients with Acute Lymphoblastic Leukemia (ALL).

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Journal:  Pathol Oncol Res       Date:  2018-11-15       Impact factor: 3.201

Review 3.  Advances in Electrochemical and Acoustic Aptamer-Based Biosensors and Immunosensors in Diagnostics of Leukemia.

Authors:  Tibor Hianik
Journal:  Biosensors (Basel)       Date:  2021-05-31
  3 in total

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