Geng Tian1, Yong Xiao, Bin Chen, Jun Xia, Hong Guan, Qunyi Deng. 1. Department of Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, 518035, China. gengtian71@yahoo.cn
Abstract
BACKGROUND: Tuberculosis (TB) can produce positive signals during ¹⁸F-fluorodeoxyglucose positron emission/computed tomography (FDG PET/CT) scanning. Until now, there has been no better method than clinical assessment to evaluate the therapeutic response of non-respiratory TB (NRTB). PURPOSE: To retrospectively assess the ability of FDG PET/CT to evaluate the response to anti-TB treatment in patients with NRTB. MATERIAL AND METHODS: Three patients with multi-site NRTB underwent repeat PET/CT scans during anti-TB treatment. Changes in maximal standard uptake value (SUVmax) of the TB lesions on PET/CT images were analyzed between two scans. Initial PET/CT scans were performed before the start of anti-TB treatment, and later scans were performed after completion of the treatment. RESULTS: Patient 1, a 63-year-old female, and patient 2, a 50-year-old male, were diagnosed as multi-site NRTB by biopsy. Patient 3, a 37-year-old male was diagnosed clinically. These patients demonstrated multiple FDG-avid lesions in whole body on initial PET/CT images. The highest SUVmax of patient 1, 2, and 3 were 13.6, 17.7, and 13.9 separately. After completion of the treatment, all positive signals of patient 1, 2, and 3 decreased to undetectable value on repeated PET/CT scans with intervals of 318 days, 258 days, and 182 days separately. CONCLUSION: FDG PET/CT scan may be useful for monitoring responses to anti-TB treatment in patients with NRTB.
BACKGROUND:Tuberculosis (TB) can produce positive signals during ¹⁸F-fluorodeoxyglucose positron emission/computed tomography (FDG PET/CT) scanning. Until now, there has been no better method than clinical assessment to evaluate the therapeutic response of non-respiratory TB (NRTB). PURPOSE: To retrospectively assess the ability of FDG PET/CT to evaluate the response to anti-TB treatment in patients with NRTB. MATERIAL AND METHODS: Three patients with multi-site NRTB underwent repeat PET/CT scans during anti-TB treatment. Changes in maximal standard uptake value (SUVmax) of the TB lesions on PET/CT images were analyzed between two scans. Initial PET/CT scans were performed before the start of anti-TB treatment, and later scans were performed after completion of the treatment. RESULTS:Patient 1, a 63-year-old female, and patient 2, a 50-year-old male, were diagnosed as multi-site NRTB by biopsy. Patient 3, a 37-year-old male was diagnosed clinically. These patients demonstrated multiple FDG-avid lesions in whole body on initial PET/CT images. The highest SUVmax of patient 1, 2, and 3 were 13.6, 17.7, and 13.9 separately. After completion of the treatment, all positive signals of patient 1, 2, and 3 decreased to undetectable value on repeated PET/CT scans with intervals of 318 days, 258 days, and 182 days separately. CONCLUSION: FDG PET/CT scan may be useful for monitoring responses to anti-TB treatment in patients with NRTB.
Authors: Philana Ling Lin; Teresa Coleman; Jonathan P J Carney; Brian J Lopresti; Jaime Tomko; Dan Fillmore; Veronique Dartois; Charles Scanga; L James Frye; Christopher Janssen; Edwin Klein; Clifton E Barry; JoAnne L Flynn Journal: Antimicrob Agents Chemother Date: 2013-06-24 Impact factor: 5.191
Authors: Ray Y Chen; Lori E Dodd; Myungsun Lee; Praveen Paripati; Dima A Hammoud; James M Mountz; Doosoo Jeon; Nadeem Zia; Homeira Zahiri; M Teresa Coleman; Matthew W Carroll; Jong Doo Lee; Yeon Joo Jeong; Peter Herscovitch; Saher Lahouar; Michael Tartakovsky; Alexander Rosenthal; Sandeep Somaiyya; Soyoung Lee; Lisa C Goldfeder; Ying Cai; Laura E Via; Seung-Kyu Park; Sang-Nae Cho; Clifton E Barry Journal: Sci Transl Med Date: 2014-12-03 Impact factor: 17.956
Authors: Alfred O Ankrah; Tjip S van der Werf; Erik F J de Vries; Rudi A J O Dierckx; Mike M Sathekge; Andor W J M Glaudemans Journal: Clin Transl Imaging Date: 2016-03-07