| Literature DB >> 20942403 |
Renaud Millet1, Annika M Träff, Michiel L Petrus, Jan-E Bäckvall.
Abstract
β-Aminoketones obtained from imines in an organocatalytic Mannich reaction were transformed to enantio- and diastereomerically pure 1,3-aminoalcohols with two stereogenic centers via a combined reduction/dynamic kinetic asymmetric transformation. Both syn and anti diastereomers were obtained in high yield, dr, and ee.Entities:
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Year: 2010 PMID： 20942403 DOI： 10.1021/ja107857v
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419