Ming Zeng1, Yonghua Cui, Cuihuan Wu. 1. Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Abstract
OBJECTIVE: To detect the expression and relationship between somatostatin receptor 2 (SSTR2) and phosphorylated STAT3 (P-STAT3) in human olfactory neuroblastoma (ONB) and adjacent normal olfactory nerve tissue. METHOD: Immunohistochemical (IHC) staining was used to detect the expression of SSTR2 and P-STAT3 in tumor and adjacent normal olfactory nerve tissue from 11 ONB patients. RESULT: SSTR2 was mainly expressed in cell cytoplasm and the expression intensity was significantly stronger in tumor tissues than in adjacent normal tissues (P<0.01). P-STAT3 was mainly expressed in cell nuclear in tumor tissues. No expression was found in adjacent normal tissues. There was a negative correlation between the expression intensity of SSTR2 and P-STAT3 (r(s) = -0.367, P<0.05). CONCLUSION: Lower expression of SSTR2 and activation of STAT3 in ONB cells might contribute to the development of ONB.
OBJECTIVE: To detect the expression and relationship between somatostatin receptor 2 (SSTR2) and phosphorylated STAT3 (P-STAT3) in humanolfactory neuroblastoma (ONB) and adjacent normal olfactory nerve tissue. METHOD: Immunohistochemical (IHC) staining was used to detect the expression of SSTR2 and P-STAT3 in tumor and adjacent normal olfactory nerve tissue from 11 ONB patients. RESULT: SSTR2 was mainly expressed in cell cytoplasm and the expression intensity was significantly stronger in tumor tissues than in adjacent normal tissues (P<0.01). P-STAT3 was mainly expressed in cell nuclear in tumor tissues. No expression was found in adjacent normal tissues. There was a negative correlation between the expression intensity of SSTR2 and P-STAT3 (r(s) = -0.367, P<0.05). CONCLUSION: Lower expression of SSTR2 and activation of STAT3 in ONB cells might contribute to the development of ONB.
Authors: Vincent Cracolici; Eric W Wang; Paul A Gardner; Carl Snyderman; Stacey M Gargano; Simion Chiosea; Aatur D Singhi; Raja R Seethala Journal: Head Neck Pathol Date: 2021-04-30