Literature DB >> 20941592

Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule.

Benjamin D Zeitlin1, Jacques E Nör.   

Abstract

Cancer has a complex etiology and displays a wide range of cellular escape pathways that allow it to circumvent treatment. Signaling molecules functionally downstream of the circumvented pathways, and particularly at checkpoints where several of these pathways intersect, provide valuable targets for the development of novel anti-cancer drugs. Bcl-2, a pro-survival signaling molecule, is one such protein. This review examines the efficacy, potency, and function of several small molecule inhibitor drugs targeted to the Bcl-2 family of proteins. The review focuses on the compounds with most available data within the literature and discusses both the anti-cancer and the recently unveiled anti-angiogenic potential of this new class of drugs.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 20941592      PMCID： PMC3812667          DOI： 10.1007/82_2010_109

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  105 in total

1.  Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.

Authors:  Hyungjin Kim; Mubina Rafiuddin-Shah; Ho-Chou Tu; John R Jeffers; Gerard P Zambetti; James J-D Hsieh; Emily H-Y Cheng
Journal:  Nat Cell Biol       Date:  2006-11-19       Impact factor: 28.824

2.  Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins.

Authors:  D Zhai; C Jin; A C Satterthwait; J C Reed
Journal:  Cell Death Differ       Date:  2006-04-28       Impact factor: 15.828

3.  Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

Authors:  Michael Certo; Victoria Del Gaizo Moore; Mari Nishino; Guo Wei; Stanley Korsmeyer; Scott A Armstrong; Anthony Letai
Journal:  Cancer Cell       Date:  2006-05       Impact factor: 31.743

4.  Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.

Authors:  Benjamin D Zeitlin; Esther Joo; Zhihong Dong; Kristy Warner; Guoping Wang; Zaneta Nikolovska-Coleska; Shaomeng Wang; Jacques E Nör
Journal:  Cancer Res       Date:  2006-09-01       Impact factor: 12.701

5.  Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.

Authors:  Guoping Wang; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Renxiao Wang; Guozhi Tang; Jie Guo; Sanjeev Shangary; Su Qiu; Wei Gao; Dajun Yang; Jennifer Meagher; Jeanne Stuckey; Krzysztof Krajewski; Sheng Jiang; Peter P Roller; Hatice Ozel Abaan; York Tomita; Shaomeng Wang
Journal:  J Med Chem       Date:  2006-10-19       Impact factor: 7.446

6.  The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

Authors:  Mark F van Delft; Andrew H Wei; Kylie D Mason; Cassandra J Vandenberg; Lin Chen; Peter E Czabotar; Simon N Willis; Clare L Scott; Catherine L Day; Suzanne Cory; Jerry M Adams; Andrew W Roberts; David C S Huang
Journal:  Cancer Cell       Date:  2006-11       Impact factor: 31.743

7.  Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

Authors:  Marina Konopleva; Rooha Contractor; Twee Tsao; Ismael Samudio; Peter P Ruvolo; Shinichi Kitada; Xingming Deng; Dayong Zhai; Yue-Xi Shi; Thomas Sneed; Monique Verhaegen; Maria Soengas; Vivian R Ruvolo; Teresa McQueen; Wendy D Schober; Julie C Watt; Tilahun Jiffar; Xiaoyang Ling; Frank C Marini; David Harris; Martin Dietrich; Zeev Estrov; James McCubrey; W Stratford May; John C Reed; Michael Andreeff
Journal:  Cancer Cell       Date:  2006-11       Impact factor: 31.743

8.  Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis.

Authors:  Guang Peng; Dan A Dixon; Stephanie J Muga; Theresa J Smith; Michael J Wargovich
Journal:  Mol Carcinog       Date:  2006-05       Impact factor: 4.784

9.  Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells.

Authors:  Yi-Wen Huang; Li-Shu Wang; Hsiang-Lin Chang; Weiping Ye; Michael K Dowd; Peter J Wan; Young C Lin
Journal:  Anticancer Res       Date:  2006 May-Jun       Impact factor: 2.480

10.  (-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo.

Authors:  Keith G Wolter; Steven J Wang; Bradley S Henson; Shaomeng Wang; Kent A Griffith; Bhavna Kumar; Jianyong Chen; Thomas E Carey; Carol R Bradford; Nisha J D'Silva
Journal:  Neoplasia       Date:  2006-03       Impact factor: 5.715
View more
  6 in total

1.  (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.

Authors:  Xiufeng Pang; Yuanyuan Wu; Yougen Wu; Binbin Lu; Jing Chen; Jieqiong Wang; Zhengfang Yi; Weijing Qu; Mingyao Liu
Journal:  Mol Cancer Ther       Date:  2011-03-03       Impact factor: 6.261

2.  Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells.

Authors:  Yen-Ling Lin; Yasemin Yuksel Durmaz; Jacques E Nör; Mohamed E H ElSayed
Journal:  Mol Pharm       Date:  2013-06-18       Impact factor: 4.939

3.  Inhibitor of MYC identified in a Kröhnke pyridine library.

Authors:  Jonathan R Hart; Amanda L Garner; Jing Yu; Yoshihiro Ito; Minghao Sun; Lynn Ueno; Jin-Kyu Rhee; Michael M Baksh; Eduard Stefan; Markus Hartl; Klaus Bister; Peter K Vogt; Kim D Janda
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-11       Impact factor: 11.205

4.  Modulating Effect of Enicostemma littorale on the Expression Pattern of Apoptotic, Cell Proliferative, Inflammatory and Angiogenic Markers During 7, 12-Dimethylbenz (a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis.

Authors:  Shanmugam Manoharan; Duraisamy Rajasekaran; Murugaraj Manoj Prabhakar; Sekar Karthikeyan; Asokan Manimaran
Journal:  Toxicol Int       Date:  2015 Jan-Apr

5.  Integrated Transcriptome and Metabolomic Analysis Reveal Anti-Angiogenic Properties of Disarib, a Novel Bcl2-Specific Inhibitor.

Authors:  Meghana Manjunath; Sai Swaroop; Sai Sanwid Pradhan; Raksha Rao K; Raghunandan Mahadeva; Venketesh Sivaramakrishnan; Bibha Choudhary
Journal:  Genes (Basel)       Date:  2022-07-06       Impact factor: 4.141

Review 6.  Apoptosis inducers in chronic lymphocytic leukemia.

Authors:  Christian Billard
Journal:  Oncotarget       Date:  2014-01-30
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.