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Literature DB >> 20940434

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.

Abstract

G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 20940434 PMCID： PMC3056154 DOI： 10.1152/physiol.00002.2010

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

52 in total

Review 1. The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors.

Authors: Leonardo Pardo; Xavier Deupi; Nicole Dölker; María Luz López-Rodríguez; Mercedes Campillo
Journal: Chembiochem Date: 2007-01-02 Impact factor: 3.164

2. Crystallographic analysis of primary visual photochemistry.

Authors: Hitoshi Nakamichi; Tetsuji Okada
Journal: Angew Chem Int Ed Engl Date: 2006-06-26 Impact factor: 15.336

3. Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.

Authors: Xiaojie Yao; Charles Parnot; Xavier Deupi; Venkata R P Ratnala; Gayathri Swaminath; David Farrens; Brian Kobilka
Journal: Nat Chem Biol Date: 2006-06-25 Impact factor: 15.040

Review 4. Conformational complexity of G-protein-coupled receptors.

Authors: Brian K Kobilka; Xavier Deupi
Journal: Trends Pharmacol Sci Date: 2007-07-13 Impact factor: 14.819

5. Functional dynamics of response regulators using NMR relaxation techniques.

Authors: Alexandra K Gardino; Dorothee Kern
Journal: Methods Enzymol Date: 2007 Impact factor: 1.600

Review 6. Beta-arrestin-biased ligands at seven-transmembrane receptors.

Authors: Jonathan D Violin; Robert J Lefkowitz
Journal: Trends Pharmacol Sci Date: 2007-07-20 Impact factor: 14.819

Review 7. Activation of G protein-coupled receptors.

Authors: Xavier Deupi; Brian Kobilka
Journal: Adv Protein Chem Date: 2007

8. G protein-coupled receptors sense fluid shear stress in endothelial cells.

Authors: Mirianas Chachisvilis; Yan-Liang Zhang; John A Frangos
Journal: Proc Natl Acad Sci U S A Date: 2006-10-09 Impact factor: 11.205

9. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Authors: Søren G F Rasmussen; Hee-Jung Choi; Daniel M Rosenbaum; Tong Sun Kobilka; Foon Sun Thian; Patricia C Edwards; Manfred Burghammer; Venkata R P Ratnala; Ruslan Sanishvili; Robert F Fischetti; Gebhard F X Schertler; William I Weis; Brian K Kobilka
Journal: Nature Date: 2007-10-21 Impact factor: 49.962

Review 10. Structural and functional properties of metarhodopsin III: recent spectroscopic studies on deactivation pathways of rhodopsin.

Authors: Franz J Bartl; Reiner Vogel
Journal: Phys Chem Chem Phys Date: 2007-01-10 Impact factor: 3.676

109 in total

1. Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.

Authors: Abdullah Mayati; Nicolas Levoin; Hervé Paris; Monique N'Diaye; Arnaud Courtois; Philippe Uriac; Dominique Lagadic-Gossmann; Olivier Fardel; Eric Le Ferrec
Journal: J Biol Chem Date: 2011-12-13 Impact factor: 5.157

10. Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.

Authors: Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida
Journal: J Biol Chem Date: 2013-02-18 Impact factor: 5.157

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.

Review 1. The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors.

2. Crystallographic analysis of primary visual photochemistry.

3. Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.

Review 4. Conformational complexity of G-protein-coupled receptors.

5. Functional dynamics of response regulators using NMR relaxation techniques.

Review 6. Beta-arrestin-biased ligands at seven-transmembrane receptors.

Review 7. Activation of G protein-coupled receptors.

8. G protein-coupled receptors sense fluid shear stress in endothelial cells.

9. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Review 10. Structural and functional properties of metarhodopsin III: recent spectroscopic studies on deactivation pathways of rhodopsin.

1. Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.

Review 2. Ice breaking in GPCR structural biology.

Review 3. Ensemble of G protein-coupled receptor active states.

Review 4. Superagonism at G protein-coupled receptors and beyond.

5. Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.

Review 6. Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

7. Molecular dynamics: A stitch in time.

Review 8. The concept of allosteric interaction and its consequences for the chemistry of the brain.

9. Molecular modeling studies give hint for the existence of a symmetric hβ₂R-Gαβγ-homodimer.

10. Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.