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Literature DB >> 20940432

Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans.

Abstract

Metazoan diversification occurred during a time when atmospheric oxygen levels fluctuated between 15 and 30%. The hypoxia-inducible factor (HIF) is a primary regulator of the adaptive transcriptional response to hypoxia. Although the HIF pathway is highly conserved, its complexity increased during periods when atmospheric oxygen concentrations were increasing. Thus atmospheric oxygen levels may have provided a selection force on the development of cellular oxygen-sensing pathways.

Entities: Chemical Disease

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Year: 2010 PMID： 20940432 DOI： 10.1152/physiol.00029.2010

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

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Cited

51 in total

1. Oxygen's double-edged sword: balancing muscle O2 supply and use during exercise.

Authors: David C Poole
Journal: J Physiol Date: 2011-02-01 Impact factor: 5.182

2. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.

Authors: Tobias Eckle; Emily M Kewley; Kelley S Brodsky; Eunyoung Tak; Stephanie Bonney; Merit Gobel; Devon Anderson; Louise E Glover; Ann K Riegel; Sean P Colgan; Holger K Eltzschig
Journal: J Immunol Date: 2014-01-03 Impact factor: 5.422

Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans.

1. Oxygen's double-edged sword: balancing muscle O2 supply and use during exercise.

2. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.

3. Hypoxia and inflammation are two sides of the same coin.

4. Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.

Review 5. Hypoxia signaling during acute lung injury.

Review 6. Attenuating myocardial ischemia by targeting A2B adenosine receptors.

Review 7. Adenosine A₂a receptors and O₂ sensing in development.

Review 8. Carbon dioxide-sensing in organisms and its implications for human disease.

Review 9. The role of hyperoxia in the pathogenesis of experimental BPD.

Review 10. Hypoxia-dependent regulation of inflammatory pathways in immune cells.