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Literature DB >> 20938532

Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor.

Neil S Keddie¹, Yulin Ye, Tashfeen Aslam, Tomas Luyten, Davide Bello, Clive Garnham, Geert Bultynck, Antony Galione, Stuart J Conway.

Abstract

The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.

Entities: Chemical

Mesh：

Substances：

Year: 2010 PMID： 20938532 DOI： 10.1039/c0cc03003a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

6 in total

Review 1. The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Authors: Mark P Thomas; Stephen J Mills; Barry V L Potter
Journal: Angew Chem Int Ed Engl Date: 2015-12-22 Impact factor: 15.336

2. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

Authors: Geert Bultynck; Santeri Kiviluoto; Nadine Henke; Hristina Ivanova; Lars Schneider; Volodymyr Rybalchenko; Tomas Luyten; Koen Nuyts; Wim De Borggraeve; Ilya Bezprozvanny; Jan B Parys; Humbert De Smedt; Ludwig Missiaen; Axel Methner
Journal: J Biol Chem Date: 2011-11-28 Impact factor: 5.157

6. Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P₃ Receptor.

Authors: Megan L Shipton; Andrew M Riley; Ana M Rossi; Charles A Brearley; Colin W Taylor; Barry V L Potter
Journal: J Med Chem Date: 2020-05-06 Impact factor: 7.446

6 in total

Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor.

Review 1. The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

2. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

3. Multivalent benzene polyphosphate derivatives are non-Ca²⁺-mobilizing Ins(1,4,5)P₃ receptor antagonists.

Review 4. Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

5. The discovery and development of IP3 receptor modulators: an update.

6. Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P₃ Receptor.

Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor.

Review 1. The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

2. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

3. Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists.

Review 4. Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

5. The discovery and development of IP3 receptor modulators: an update.

6. Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3 Receptor.

3. Multivalent benzene polyphosphate derivatives are non-Ca²⁺-mobilizing Ins(1,4,5)P₃ receptor antagonists.

6. Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P₃ Receptor.