Literature DB >> 20938157

Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown.

A D Pradhan1, A M Case, R G Farrer, S Y Tsai, J L Cheatwood, J L Martin, G L Kartje.   

Abstract

The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells.
Copyright © 2010 S. Karger AG, Basel.

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Year:  2010        PMID: 20938157      PMCID: PMC3021499          DOI: 10.1159/000309135

Source DB:  PubMed          Journal:  Dev Neurosci        ISSN: 0378-5866            Impact factor:   2.984


  44 in total

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