| Literature DB >> 20938157 |
A D Pradhan1, A M Case, R G Farrer, S Y Tsai, J L Cheatwood, J L Martin, G L Kartje.
Abstract
The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells.Entities:
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Year: 2010 PMID: 20938157 PMCID: PMC3021499 DOI: 10.1159/000309135
Source DB: PubMed Journal: Dev Neurosci ISSN: 0378-5866 Impact factor: 2.984