Roger E Thomas1, Tom Jefferson, Toby J Lasserson. 1. Department of Family Medicine, University of Calgary Medical Clinics North Hill, University of Calgary, 1707-1632 14 Avenue NW, Calgary, Canada T2M1M1. rthomas@ucalgary.ca
Abstract
AIM: To identify studies of influenza vaccination of HCWs and influenza in elderly residents in long-term care facilities. SCOPE: We searched seven electronic databases for randomised controlled trials (RCTs) and non-RCTs. Two reviewers independently extracted data and assessed trial quality. CONCLUSIONS: The key outcomes are serologically proven influenza, pneumonia, and deaths from pneumonia, and pooled data from three C-RCTs showed no effect. Pooled data from three C-RCTs showed lower resident all-cause mortality, but as influenza constituted less than 10% of all deaths even in epidemic years we question the appropriateness of this outcome measure. Pooled data from three C-RCTs showed vaccination of HCWs reduced ILI and data from one C-RCT that HCW vaccination reduced GP consultations for ILI, but as influenza constitutes less than 25% of ILI and we did not show that HCW influenza vaccination reduced serologically proven influenza we question whether this effect is due to confounding.
AIM: To identify studies of influenza vaccination of HCWs and influenza in elderly residents in long-term care facilities. SCOPE: We searched seven electronic databases for randomised controlled trials (RCTs) and non-RCTs. Two reviewers independently extracted data and assessed trial quality. CONCLUSIONS: The key outcomes are serologically proven influenza, pneumonia, and deaths from pneumonia, and pooled data from three C-RCTs showed no effect. Pooled data from three C-RCTs showed lower resident all-cause mortality, but as influenza constituted less than 10% of all deaths even in epidemic years we question the appropriateness of this outcome measure. Pooled data from three C-RCTs showed vaccination of HCWs reduced ILI and data from one C-RCT that HCW vaccination reduced GP consultations for ILI, but as influenza constitutes less than 25% of ILI and we did not show that HCW influenza vaccination reduced serologically proven influenza we question whether this effect is due to confounding.
Authors: Megan C Lindley; Suchita A Lorick; Anita Geevarughese; Soo-Jeong Lee; Monear Makvandi; Brady L Miller; David A Nace; Carmela Smith; Faruque Ahmed Journal: Am J Prev Med Date: 2013-09 Impact factor: 5.043
Authors: Josien Riphagen-Dalhuisen; Gerard Frijstein; Nannet van der Geest-Blankert; Marita Danhof-Pont; Herbert de Jager; Nita Bos; Ed Smeets; Marjan de Vries; Pieter Gallee; Eelko Hak Journal: BMC Infect Dis Date: 2013-05-23 Impact factor: 3.090