H-B Xu1, R-H Jiang, L Li, W Sha, H-P Xiao. 1. Department of Clinical Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Abstract
OBJECTIVE: To determine the accuracy of adenosine deaminase (ADA) measurements in the diagnosis of tuberculous meningitis (TBM). DESIGN: After a systematic review of English language studies, the sensitivity, specificity and accuracy of ADA concentrations in the diagnosis of cerebrospinal fluid (CSF) were evaluated using random effects models. Summary receiver operating characteristic curves were used to summarise overall test performance. RESULTS: Ten studies met our inclusion criteria. The sensitivity of ADA in the diagnosis of TBM was 0.79 (95%CI 0.75-0.83), specificity 0.91 (95%CI 0.89-0.93), positive likelihood ratio 6.85 (95%CI 4.11-11.41), negative likelihood ratio 0.29 (95%CI 0.19-0.44) and diagnostic odds ratio 26.93 (95%CI 12.73-56.97). CONCLUSION: Our data suggest that ADA in the CSF can be a sensitive and specific target and a critical criteria for the diagnosis of TBM.
OBJECTIVE: To determine the accuracy of adenosine deaminase (ADA) measurements in the diagnosis of tuberculous meningitis (TBM). DESIGN: After a systematic review of English language studies, the sensitivity, specificity and accuracy of ADA concentrations in the diagnosis of cerebrospinal fluid (CSF) were evaluated using random effects models. Summary receiver operating characteristic curves were used to summarise overall test performance. RESULTS: Ten studies met our inclusion criteria. The sensitivity of ADA in the diagnosis of TBM was 0.79 (95%CI 0.75-0.83), specificity 0.91 (95%CI 0.89-0.93), positive likelihood ratio 6.85 (95%CI 4.11-11.41), negative likelihood ratio 0.29 (95%CI 0.19-0.44) and diagnostic odds ratio 26.93 (95%CI 12.73-56.97). CONCLUSION: Our data suggest that ADA in the CSF can be a sensitive and specific target and a critical criteria for the diagnosis of TBM.
Authors: Cuong Chi Ngo; Shungo Katoh; Futoshi Hasebe; Bhim Gopal Dhoubhadel; Tomoko Hiraoka; Sugihiro Hamaguchi; Anh Thi Kim Le; Anh Thi Hien Nguyen; Anh Duc Dang; Chris Smith; Lay-Myint Yoshida; Cuong Duy Do; Thuy Thi Thanh Pham; Koya Ariyoshi Journal: Trop Med Health Date: 2021-05-21
Authors: Jorge Parra-Ruiz; V Ramos; C Dueñas; N M Coronado-Álvarez; R Cabo-Magadán; V Portillo-Tuñón; D Vinuesa; L Muñoz-Medina; J Hernández-Quero Journal: Infection Date: 2015-04-14 Impact factor: 3.553