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Literature DB >> 2093696

The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients.

A Dmoszyńska-Giannopoulou¹, L Janicka, B Sokołowska, A Ksiazek, G Orłowska, K Janicki.

Abstract

In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.

Entities: Chemical Disease Species

Mesh：

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Year: 1990 PMID： 2093696 DOI： 10.1007/BF02549745

Source DB: PubMed Journal: Int Urol Nephrol ISSN： 0301-1623 Impact factor: 2.370

12 in total

1. Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors: G V BORN
Journal: Nature Date: 1962-06-09 Impact factor: 49.962

2. A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency.

Authors: K K Wu; J C Hoak
Journal: Lancet Date: 1974-10-19 Impact factor: 79.321

3. Functional and structural aspects of biological membranes: a suggested structural role for vitamin E in the control of membrane permeability and stability.

Authors: J A Lucy
Journal: Ann N Y Acad Sci Date: 1972-12-18 Impact factor: 5.691

Review 4. Platelet suppressive therapy in clinical medicine.

Authors: F E Preston; M Greaves
Journal: Br J Haematol Date: 1985-08 Impact factor: 6.998

5. Vitamin E. An inhibitor of the platelet release reaction.

Authors: M Steiner; J Anastasi
Journal: J Clin Invest Date: 1976-03 Impact factor: 14.808

6. Dietary supplementation with vitamin E in hyperlipoproteinemias: effects on plasma lipid peroxides, antioxidant activity, prostacyclin generation and platelet aggregability.

Authors: A Szczeklik; R J Gryglewski; B Domagala; R Dworski; M Basista
Journal: Thromb Haemost Date: 1985-08-30 Impact factor: 5.249

The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients.

1. Aggregation of blood platelets by adenosine diphosphate and its reversal.

2. A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency.

3. Functional and structural aspects of biological membranes: a suggested structural role for vitamin E in the control of membrane permeability and stability.

Review 4. Platelet suppressive therapy in clinical medicine.

5. Vitamin E. An inhibitor of the platelet release reaction.

6. Dietary supplementation with vitamin E in hyperlipoproteinemias: effects on plasma lipid peroxides, antioxidant activity, prostacyclin generation and platelet aggregability.

7. The effect of sulphinpyrazone and its metabolites on platelet function in vitro and ex vivo.

8. Alpha-tocopherol, a potent modulator of endothelial cell function.

9. Effect of alpha-tocopherol administration on platelet function in man.

10. Effect of vitamin E on platelet aggregation in diabetes mellitus.

Review 1. Antiplatelet agents for chronic kidney disease.