Lubin Liu1, Deng Li, Yanzhou Wang, Huicheng Xu, Liangpeng Ge, Zhiqing Liang. 1. Department of Obstetrics and Gynecologyy, Southwestern Hospital, Third Military Medical University, Gao-tan Yan Street, Shapingba District, Chongqing, 400038, People's Republic of China.
Abstract
INTRODUCTION AND HYPOTHESIS: Xenogeneic (porcine) extracellular matrix (ECM) scaffolds have been suggested as ideal biomaterials for regeneration medicine; however, ECM prepared from different tissue sources has shown distinctive biological properties. Therefore, a comprehensive understanding of biological characteristics of different tissue-derived ECM is essential in the design of scaffolds for pelvic reconstruction. METHODS: We compared the biological properties of ECM derived from different tissue sources of Bama miniature pigs as a pelvic biological patch in terms of histological structure, water absorption ability, biodegradation ability, mechanical properties, antimicrobial activity, and biocompatibility in vitro. RESULTS: Different ECM scaffolds have distinct structural differences, and all have good biocompatibility, and UBM exhibited better water uptake ability (above 500%), anti-biodegradation ability, mechanical properties, antimicrobial activity, and stem cell attachment properties than other tissue-derived ECM. CONCLUSIONS: Porcine UBM might serve as an ideal pelvic biological patch.
INTRODUCTION AND HYPOTHESIS: Xenogeneic (porcine) extracellular matrix (ECM) scaffolds have been suggested as ideal biomaterials for regeneration medicine; however, ECM prepared from different tissue sources has shown distinctive biological properties. Therefore, a comprehensive understanding of biological characteristics of different tissue-derived ECM is essential in the design of scaffolds for pelvic reconstruction. METHODS: We compared the biological properties of ECM derived from different tissue sources of Bama miniature pigs as a pelvic biological patch in terms of histological structure, water absorption ability, biodegradation ability, mechanical properties, antimicrobial activity, and biocompatibility in vitro. RESULTS: Different ECM scaffolds have distinct structural differences, and all have good biocompatibility, and UBM exhibited better water uptake ability (above 500%), anti-biodegradation ability, mechanical properties, antimicrobial activity, and stem cell attachment properties than other tissue-derived ECM. CONCLUSIONS: Porcine UBM might serve as an ideal pelvic biological patch.
Authors: Daniel Altman; Annika López; Catharina Gustafsson; Christian Falconer; Johan Nordenstam; Jan Zetterström Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2005-04-05
Authors: Lars Steinstraesser; Till Koehler; Frank Jacobsen; Adrien Daigeler; Ole Goertz; Stefan Langer; Marco Kesting; Hans Steinau; Elof Eriksson; Tobias Hirsch Journal: Mol Med Date: 2008 Jul-Aug Impact factor: 6.354
Authors: Donald O Freytes; Stephen F Badylak; Thomas J Webster; Leslie A Geddes; Ann E Rundell Journal: Biomaterials Date: 2004-05 Impact factor: 12.479
Authors: Aradhana Mehta; Rami Afshar; David L Warner; Amy Gardner; Ellen Ackerman; Jared Brandt; Kent C Sasse Journal: JSLS Date: 2017 Jan-Mar Impact factor: 2.172
Authors: K C Sasse; J-H Lambin; J Gevorkian; C Elliott; R Afshar; A Gardner; A Mehta; R Lambin; L Peraza Journal: Hernia Date: 2018-10-01 Impact factor: 4.739