Literature DB >> 20936095

Fluorine-18 chemistry in micro-reactors.

Shuiyu Lu1, Joong-Hyun Chun, Victor W Pike.   

Abstract

Recent applications of micro-reactor (microfluidics) technology to radiofluorination chemistry within our laboratory are presented, based on use of either a simple T-shaped glass micro-reactor or a more advanced microfluidics instrument. The topics include reaction optimization and radioligand production, in particular the study of the radiofluorination of diaryliodonium salts, [(18)F]fluoride ion exchange with xenon difluoride(,) esterification with [(18)F]2-fluoroethyl tosylate, and the syntheses of [(18)F]fallypride, [(18)F]FBR and [(18)F]SL702 from [(18)F]fluoride ion.

Entities:  

Year:  2010        PMID： 20936095      PMCID： PMC2950705     

Source DB:  PubMed          Journal:  J Labelled Comp Radiopharm        ISSN： 0362-4803            Impact factor:   1.921


  10 in total

1.  Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics.

Authors:  Chung-Cheng Lee; Guodong Sui; Arkadij Elizarov; Chengyi Jenny Shu; Young-Shik Shin; Alek N Dooley; Jiang Huang; Antoine Daridon; Paul Wyatt; David Stout; Hartmuth C Kolb; Owen N Witte; Nagichettiar Satyamurthy; James R Heath; Michael E Phelps; Stephen R Quake; Hsian-Rong Tseng
Journal:  Science       Date:  2005-12-16       Impact factor: 47.728

Review 2.  Pivotal role of nanotechnologies and biotechnologies for molecular imaging and therapy.

Authors:  Giovanni Lucignani
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-07       Impact factor: 9.236

Review 3.  Microreactors for radiopharmaceutical synthesis.

Authors:  Arkadij M Elizarov
Journal:  Lab Chip       Date:  2009-03-26       Impact factor: 6.799

4.  Microfluidic reactor for the radiosynthesis of PET radiotracers.

Authors:  J M Gillies; C Prenant; G N Chimon; G J Smethurst; W Perrie; I Hamblett; B Dekker; J Zweit
Journal:  Appl Radiat Isot       Date:  2005-11-15       Impact factor: 1.513

5.  Xenon difluoride exchanges fluoride under mild conditions: a simple preparation of [(18)F]xenon difluoride for PET and mechanistic studies.

Authors:  M Constantinou; F I Aigbirhio; R G Smith; C A Ramsden; V W Pike
Journal:  J Am Chem Soc       Date:  2001-02-28       Impact factor: 15.419

6.  Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride.

Authors:  J Mukherjee; Z Y Yang; T Brown; R Lew; M Wernick; X Ouyang; N Yasillo; C T Chen; R Mintzer; M Cooper
Journal:  Nucl Med Biol       Date:  1999-07       Impact factor: 2.408

7.  Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor.

Authors:  Shui-Yu Lu; Paul Watts; Frederick T Chin; Jinsoo Hong; John L Musachio; Emmanuelle Briard; Victor W Pike
Journal:  Lab Chip       Date:  2004-09-28       Impact factor: 6.799

8.  Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain.

Authors:  Masao Imaizumi; Emmanuelle Briard; Sami S Zoghbi; Jonathan P Gourley; Jinsoo Hong; John L Musachio; Robert Gladding; Victor W Pike; Robert B Innis; Masahiro Fujita
Journal:  Synapse       Date:  2007-08       Impact factor: 2.562

9.  Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.

Authors:  Emmanuelle Briard; Sami S Zoghbi; Fabrice G Siméon; Masao Imaizumi; Jonathan P Gourley; H Umesha Shetty; Shuiyu Lu; Masahiro Fujita; Robert B Innis; Victor W Pike
Journal:  J Med Chem       Date:  2009-02-12       Impact factor: 7.446

10.  Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06.

Authors:  Yota Fujimura; Sami S Zoghbi; Fabrice G Simèon; Andrew Taku; Victor W Pike; Robert B Innis; Masahiro Fujita
Journal:  J Nucl Med       Date:  2009-06-12       Impact factor: 10.057
  10 in total
  2 in total

1.  Ultra-compact, automated microdroplet radiosynthesizer.

Authors:  Jia Wang; Philip H Chao; R Michael van Dam
Journal:  Lab Chip       Date:  2019-06-12       Impact factor: 6.799

2.  Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production.

Authors:  Christopher Frank; Georg Winter; Fredrik Rensei; Victor Samper; Allen F Brooks; Brian G Hockley; Bradford D Henderson; Christian Rensch; Peter J H Scott
Journal:  EJNMMI Radiopharm Chem       Date:  2019-09-18
  2 in total

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