Literature DB >> 20936082

Efficient microwave-assisted one-pot preparation of angular 2,2-dimethyl-2H-chromone containing compounds.

Ting Zhou1, Qian Shi, Kuo Hsing Lee.   

Abstract

A novel and efficient microwave-assisted one-pot reaction was developed to synthesize angular 2,2-dimethyl-2H-chromone containing compounds, which is the first and key step in the synthesis of potent DCK and DCP anti-HIV agents. The newly developed microwave synthesis conditions dramatically shortened the reaction time from 2 days to 4 hours with improved yields.

Entities:  

Year:  2010        PMID： 20936082      PMCID： PMC2950643          DOI： 10.1016/j.tetlet.2010.06.058

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  6 in total

1.  2,2-dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties.

Authors:  A F M Motiur Rahman; Jing Lu Liang; Seung Ho Lee; Jong Keun Son; Mi-Ja Jung; Youngjoo Kwon; Yurngdong Jahng
Journal:  Arch Pharm Res       Date:  2008-09-20       Impact factor: 4.946

2.  Synthesis and biological activity of acronycine analogs.

Authors:  J Schneider; E L Evans; E Grunberg; R I Fryer
Journal:  J Med Chem       Date:  1972-03       Impact factor: 7.446

3.  Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.

Authors:  L Xie; Y Takeuchi; L M Cosentino; K H Lee
Journal:  J Med Chem       Date:  1999-07-15       Impact factor: 7.446

4.  Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents.

Authors:  Donglei Yu; Chin-Ho Chen; Arnold Brossi; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2004-07-29       Impact factor: 7.446

5.  Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent.

Authors:  Donglei Yu; Arnold Brossi; Nicole Kilgore; Carl Wild; Graham Allaway; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2003-05-05       Impact factor: 2.823

6.  Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.

Authors:  T T Lee; Y Kashiwada; L Huang; J Snider; M Cosentino; K H Lee
Journal:  Bioorg Med Chem       Date:  1994-10       Impact factor: 3.641
  6 in total
  7 in total

1.  Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.

Authors:  Ting Zhou; Qian Shi; Chin-Ho Chen; Li Huang; Phong Ho; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Eur J Med Chem       Date:  2011-10-20       Impact factor: 6.514

2.  Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.

Authors:  Ting Zhou; Emika Ohkoshi; Qian Shi; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2012-03-13       Impact factor: 2.823

3.  Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R-disubstituted-2',2'-dimethyldihydropyrano[2,3-f]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance.

Authors:  Ting Zhou; Qian Shi; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2010-11-17       Impact factor: 7.446

4.  Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase.

Authors:  Annah N Mpitimpiti; Jacobus P Petzer; Anél Petzer; Johannes H L Jordaan; Anna C U Lourens
Journal:  Mol Divers       Date:  2019-01-21       Impact factor: 2.943

5.  Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A.

Authors:  Qiao Li; Chen Zhuang; Donghua Wang; Wei Zhang; Rongxuan Jia; Fengxia Sun; Yilin Zhang; Yunfei Du
Journal:  Beilstein J Org Chem       Date:  2019-12-12       Impact factor: 2.883

6.  Molecular structure, NBO analysis of the hydrogen-bonded interactions, spectroscopic (FT-IR, FT-Raman), drug likeness and molecular docking of the novel anti COVID-2 molecule (2E)-N-methyl-2-[(4-oxo-4H-chromen-3-yl)methylidene]-hydrazinecarbothioamide (Dimer) - quantum chemical approach.

Authors:  S J Jenepha Mary; Sayantan Pradhan; C James
Journal:  Spectrochim Acta A Mol Biomol Spectrosc       Date:  2020-12-29       Impact factor: 4.098

7.  Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity.

Authors:  Jianan Sun; Jiahui Mu; Shenglin Wang; Cai Jia; Dahong Li; Huiming Hua; Hao Cao
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051
  7 in total

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