Literature DB >> 20935670

The Achilles heel of γ-secretase: can we contain Alzheimer's disease by reducing synthesis of β-amyloid?

Alexei Verkhratsky1, José Julio Rodríguez.   

Abstract

Entities:  

Year:  2010        PMID： 20935670      PMCID： PMC4003337          DOI： 10.1038/aps.2010.189

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


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  13 in total

1.  Cell death or synaptic loss in Alzheimer disease.

Authors:  R D Terry
Journal:  J Neuropathol Exp Neurol       Date:  2000-12       Impact factor: 3.685

Review 2.  Alzheimer's disease is a synaptic failure.

Authors:  Dennis J Selkoe
Journal:  Science       Date:  2002-10-25       Impact factor: 47.728

Review 3.  Astroglia in dementia and Alzheimer's disease.

Authors:  J J Rodríguez; M Olabarria; A Chvatal; A Verkhratsky
Journal:  Cell Death Differ       Date:  2008-12-05       Impact factor: 15.828

Review 4.  A century-old debate on protein aggregation and neurodegeneration enters the clinic.

Authors:  Peter T Lansbury; Hilal A Lashuel
Journal:  Nature       Date:  2006-10-19       Impact factor: 49.962

5.  Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease.

Authors:  Markel Olabarria; Harun N Noristani; Alexei Verkhratsky; José J Rodríguez
Journal:  Glia       Date:  2010-05       Impact factor: 7.452

6.  Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease.

Authors:  J J Rodríguez; J Witton; M Olabarria; H N Noristani; A Verkhratsky
Journal:  Cell Death Dis       Date:  2010       Impact factor: 8.469

7.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

Authors:  Gen He; Wenjie Luo; Peng Li; Christine Remmers; William J Netzer; Joseph Hendrick; Karima Bettayeb; Marc Flajolet; Fred Gorelick; Lawrence P Wennogle; Paul Greengard
Journal:  Nature       Date:  2010-09-02       Impact factor: 49.962

Review 8.  Neuroglia in neurodegeneration.

Authors:  Michael T Heneka; José J Rodríguez; Alexei Verkhratsky
Journal:  Brain Res Rev       Date:  2009-11-26

Review 9.  A focus on the synapse for neuroprotection in Alzheimer disease and other dementias.

Authors:  Paul Coleman; Howard Federoff; Roger Kurlan
Journal:  Neurology       Date:  2004-10-12       Impact factor: 9.910

10.  Gleevec inhibits beta-amyloid production but not Notch cleavage.

Authors:  William J Netzer; Fei Dou; Dongming Cai; Darren Veach; Stephanie Jean; Yueming Li; William G Bornmann; Bayard Clarkson; Huaxi Xu; Paul Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-01       Impact factor: 11.205
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