Literature DB >> 20935489

Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: slayer or savior?

Yingmei Zhang1, Jun Ren.   

Abstract

The mitochondrial isoform of aldehyde dehydrogenase (ALDH2) plays a key role in the metabolism of acetaldehyde and other toxic aldehydes. A recent seminal finding has indicated a potential role of ALDH2 activation in the cardioprotection against ischemic injury. Data from our group unveiled a myocardial protective effect of ALDH2 against ischemia/reperfusion (I/R) injury possibly through detoxification of toxic aldehydes: and a differential regulation of autophagy mediated by AMPK-mTOR and Akt-mTOR signaling cascades during ischemia and reperfusion, respectively. These findings suggest not only the therapeutic potential of ALDH2 against I/R injury but also a pivotal role of the AMPK-Akt-mTOR signaling in the paradoxical autophagic regulation of cardiomyocyte survival.

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Year:  2010        PMID： 20935489     DOI： 10.4161/auto.6.8.13652

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  13 in total

1.  Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin.

Authors:  Vishal R Mali; Ruizhuo Ning; Jieli Chen; Xiao-Ping Yang; Jiang Xu; Suresh S Palaniyandi
Journal:  Exp Biol Med (Maywood)       Date:  2014-03-20

Review 2.  ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications.

Authors:  Yingmei Zhang; Jun Ren
Journal:  Pharmacol Ther       Date:  2011-06-12       Impact factor: 12.310

Review 3.  Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.

Authors:  Che-Hong Chen; Julio Cesar Batista Ferreira; Eric R Gross; Daria Mochly-Rosen
Journal:  Physiol Rev       Date:  2014-01       Impact factor: 37.312

4.  AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol.

Authors:  Wei Ge; Rui Guo; Jun Ren
Journal:  Free Radic Biol Med       Date:  2011-08-10       Impact factor: 7.376

5.  Pterostilbene induces Nrf2/HO-1 and potentially regulates NF-κB and JNK-Akt/mTOR signaling in ischemic brain injury in neonatal rats.

Authors:  Qinghuang Zeng; Wenchang Lian; Guizhi Wang; Manping Qiu; Lingmu Lin; Renhe Zeng
Journal:  3 Biotech       Date:  2020-04-04       Impact factor: 2.406

Review 6.  Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.

Authors:  Jun Ren; Ne N Wu; Shuyi Wang; James R Sowers; Yingmei Zhang
Journal:  Physiol Rev       Date:  2021-05-05       Impact factor: 37.312

7.  mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism.

Authors:  Wei Ge; Jun Ren
Journal:  J Cell Mol Med       Date:  2012-03       Impact factor: 5.310

8.  Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α.

Authors:  Nan Hu; Jun Ren; Yingmei Zhang
Journal:  Oncotarget       Date:  2016-11-22

9.  Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy.

Authors:  Machender R Kandadi; Xuejun Yu; Arthur E Frankel; Jun Ren
Journal:  BMC Med       Date:  2012-11-07       Impact factor: 8.775

Review 10.  Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update.

Authors:  Arnau Panisello-Roselló; Alexandre Lopez; Emma Folch-Puy; Teresa Carbonell; Anabela Rolo; Carlos Palmeira; René Adam; Marc Net; Joan Roselló-Catafau
Journal:  World J Gastroenterol       Date:  2018-07-21       Impact factor: 5.742
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