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Literature DB >> 20935483

The genetic architecture of aging: sexual antagonistic pleiotropy of p53 and foxo.

John Tower.

Abstract

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20935483 PMCID： PMC5644342 DOI： 10.4161/cc.9.19.13464

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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11 in total

1. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.

Authors: M Tatar; A Kopelman; D Epstein; M P Tu; C M Yin; R S Garofalo
Journal: Science Date: 2001-04-06 Impact factor: 47.728

2. Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster.

Authors: S V Nuzhdin; E G Pasyukova; C L Dilda; Z B Zeng; T F Mackay
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

Review 3. Evolutionary and mechanistic theories of aging.

Authors: Kimberly A Hughes; Rose M Reynolds
Journal: Annu Rev Entomol Date: 2005 Impact factor: 19.686

Review 4. The genetics of ageing.

Authors: Cynthia J Kenyon
Journal: Nature Date: 2010-03-25 Impact factor: 49.962

Review 5. Endocrine regulation of aging and reproduction in Drosophila.

Authors: Janne M Toivonen; Linda Partridge
Journal: Mol Cell Endocrinol Date: 2008-07-17 Impact factor: 4.102

6. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

Authors: D J Clancy; D Gems; L G Harshman; S Oldham; H Stocker; E Hafen; S J Leevers; L Partridge
Journal: Science Date: 2001-04-06 Impact factor: 47.728

Review 7. Sex-specific regulation of aging and apoptosis.

Authors: John Tower
Journal: Mech Ageing Dev Date: 2006-06-09 Impact factor: 5.432

8. Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.

Authors: Morris Waskar; Gary N Landis; Jie Shen; Christina Curtis; Kevin Tozer; Diana Abdueva; Dmitriy Skvortsov; Simon Tavaré; John Tower
Journal: Aging (Albany NY) Date: 2009-10-27 Impact factor: 5.682

6. Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster.

Authors: Gary Landis; Jie Shen; John Tower
Journal: Aging (Albany NY) Date: 2012-11 Impact factor: 5.682

Review 7. Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.

Authors: Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2013-11-15 Impact factor: 4.534

7 in total

The genetic architecture of aging: sexual antagonistic pleiotropy of p53 and foxo.

1. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.

2. Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster.

Review 3. Evolutionary and mechanistic theories of aging.

Review 4. The genetics of ageing.

Review 5. Endocrine regulation of aging and reproduction in Drosophila.

6. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

Review 7. Sex-specific regulation of aging and apoptosis.

8. Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.

9. Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects.

Review 10. Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.

1. Rapamycin induces pluripotent genes associated with avoidance of replicative senescence.

Review 2. Mitochondrial maintenance failure in aging and role of sexual dimorphism.

3. Sex-specific aging in flies, worms, and missing great-granddads.

4. Hormesis does not make sense except in the light of TOR-driven aging.

5. Sex- and mutation-specific p53 gain-of-function activity in gliomagenesis.

6. Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster.

Review 7. Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.