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Literature DB >> 20935257

A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.

Esperanza Such¹, José Cervera, Ana Valencia, Eva Barragán, Mariam Ibañez, Irene Luna, Oscar Fuster, Maria Luz Perez-Sirvent, Leonor Senent, Amparo Sempere, Jesús Martinez, Guillermo Martín-Aragonés, Miguel A Sanz.

Abstract

Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20935257 DOI： 10.1182/blood-2010-06-291658

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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Cited

23 in total

1. Identification of a novel PML-RARG fusion in acute promyelocytic leukemia.

Authors: J-S Ha; Y R Do; C-S Ki; C Lee; D-H Kim; W Lee; N-H Ryoo; D-S Jeon
Journal: Leukemia Date: 2017-05-30 Impact factor: 11.528

2. A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion.

Authors: Christopher A Miller; Christopher Tricarico; Zachary L Skidmore; Geoffrey L Uy; Yi-Shan Lee; Anjum Hassan; Michelle D O'Laughlin; Heather Schmidt; Ling Tian; Eric J Duncavage; Malachi Griffith; Obi L Griffith; John S Welch; Lukas D Wartman
Journal: Blood Adv Date: 2018-06-12

3. Clinical and molecular features of acute promyelocytic leukemia with variant retinoid acid receptor fusions.

Authors: Lijun Wen; Yang Xu; Li Yao; Nana Wang; Qinrong Wang; Tianhui Liu; Jinlan Pan; Jiannong Cen; Huifeng Zhou; Miao Miao; Yang W Shao; Xiaonan Wang; Xiaoxia Wang; Changgeng Ruan; Depei Wu; Suning Chen
Journal: Haematologica Date: 2018-09-20 Impact factor: 9.941

Review 4. NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.

Authors: Sheryl M Gough; Christopher I Slape; Peter D Aplan
Journal: Blood Date: 2011-09-26 Impact factor: 22.113

5. Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review.

Authors: Jiasheng Hu; Xiuli Hong; Zhe Li; Quanyi Lu
Journal: Oncol Lett Date: 2015-07-20 Impact factor: 2.967

6. Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.

Authors: John S Welch; Peter Westervelt; Li Ding; David E Larson; Jeffery M Klco; Shashikant Kulkarni; John Wallis; Ken Chen; Jacqueline E Payton; Robert S Fulton; Joelle Veizer; Heather Schmidt; Tammi L Vickery; Sharon Heath; Mark A Watson; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Timothy J Ley; Richard K Wilson
Journal: JAMA Date: 2011-04-20 Impact factor: 56.272

7. Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.

Authors: J J Qiu; B B Zeisig; S Li; W Liu; H Chu; Y Song; A Giordano; J Schwaller; H Gronemeyer; S Dong; C W E So
Journal: Leukemia Date: 2014-12-16 Impact factor: 11.528