An automated Hirschberg test for infants.

A novel automated method to measure eye misalignment in infants is presented. The method uses estimates of the Hirschberg ratio (HR) and angle Kappa (the angle between the visual and optical axis) for each infant to calculate the angle of eye misalignment. The HR and angle Kappa are estimated automatically from measurements of the direction of the optical axis and the coordinates of the center of the entrance pupil and corneal reflexes in each eye when infants look at a set of images that are presented sequentially on a computer monitor. The HR is determined by the slope of the line that describes the direction of the optical axis as a function of the distance between the center of the entrance pupil and the corneal reflexes. The peak of the distribution of possible angles Kappa during the image presentation determines the value of angle Kappa. Experiments with five infants showed that the 95% limits of agreement between repeated measurements of angle Kappa are ± 0.61 (°). The maximum error in the estimation of eye alignment in orthotropic infants was 0.9 (°) with 95% limits of agreement between repeated measurements of 0.75 (°).