| Literature DB >> 20934749 |
I Tirado-González1, R Muñoz-Fernández, O Blanco, E Leno-Durán, A C Abadía-Molina, E G Olivares.
Abstract
Recent studies showed that some functions of decidual dendritic cells appear to be essential for pregnancy. In humans, decidual dendritic cells are identifiable by their expression of DC-SIGN. We compared the subpopulations of human decidual DC-SIGN+ cells from first-trimester normal pregnancies and spontaneous abortions by flow cytometry. In normal decidua, DC-SIGN+ cells expressed antigens associated with immature myeloid dendritic cells. In samples from spontaneous abortions, we detected decidual DC-SIGN+ cells with an antigen phenotype equivalent to that of DC-SIGN+ cells from normal pregnancies, but at a significantly lower proportion (P < 0.01). Our results support the hypothesis that dendritic cells play a role in normal or pathological human pregnancy outcomes.Entities:
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Year: 2010 PMID： 20934749 DOI： 10.1016/j.placenta.2010.09.008
Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481