OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved. Copyright Â
OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved. Copyright Â
Authors: Samer Gawrieh; Tesfaye M Baye; Melanie Carless; James Wallace; Richard Komorowski; David E Kleiner; Deborah Andris; Bassem Makladi; Regina Cole; Michael Charlton; Joanne Curran; Thomas D Dyer; Jac Charlesworth; Russell Wilke; John Blangero; Ahmed H Kissebah; Michael Olivier Journal: Obes Surg Date: 2010-12 Impact factor: 4.129
Authors: E K Moses; E Fitzpatrick; K A Freed; T D Dyer; S Forrest; K Elliott; M P Johnson; J Blangero; S P Brennecke Journal: Mol Hum Reprod Date: 2006-06-29 Impact factor: 4.025
Authors: M De Falco; L Cobellis; D Giraldi; A Mastrogiacomo; A Perna; N Colacurci; L Miele; A De Luca Journal: Placenta Date: 2007 Feb-Mar Impact factor: 3.481
Authors: Daniel A Enquobahrie; Margaret Meller; Kenneth Rice; Bruce M Psaty; David S Siscovick; Michelle A Williams Journal: Am J Obstet Gynecol Date: 2008-06-04 Impact factor: 8.661
Authors: K Itoh; T Chiba; S Takahashi; T Ishii; K Igarashi; Y Katoh; T Oyake; N Hayashi; K Satoh; I Hatayama; M Yamamoto; Y Nabeshima Journal: Biochem Biophys Res Commun Date: 1997-07-18 Impact factor: 3.575
Authors: Hong-wa Yung; Stefania Calabrese; Debby Hynx; Brian A Hemmings; Irene Cetin; D Stephen Charnock-Jones; Graham J Burton Journal: Am J Pathol Date: 2008-06-26 Impact factor: 4.307
Authors: Roy M Nilsen; Anne-Lise Bjørke-Monsen; Oivind Midttun; Ottar Nygård; Eva R Pedersen; Arve Ulvik; Per Magnus; Håkon K Gjessing; Stein Emil Vollset; Per Magne Ueland Journal: Obstet Gynecol Date: 2012-06 Impact factor: 7.661
Authors: Asa Johansson; Joanne E Curran; Matthew P Johnson; Katy A Freed; Mona H Fenstad; Line Bjørge; Irina P Eide; Melanie A Carless; David L Rainwater; Harald H H Goring; Rigmor Austgulen; Eric K Moses; John Blangero Journal: Eur J Hum Genet Date: 2011-02-23 Impact factor: 4.246
Authors: Nisreen Kweider; Athanassios Fragoulis; Christian Rosen; Ulrich Pecks; Werner Rath; Thomas Pufe; Christoph Jan Wruck Journal: J Biol Chem Date: 2011-10-27 Impact factor: 5.157
Authors: Matthew P Johnson; Shaun P Brennecke; Christine E East; Thomas D Dyer; Linda T Roten; J Michael Proffitt; Phillip E Melton; Mona H Fenstad; Tia Aalto-Viljakainen; Kaarin Mäkikallio; Seppo Heinonen; Eero Kajantie; Juha Kere; Hannele Laivuori; Rigmor Austgulen; John Blangero; Eric K Moses Journal: Mol Hum Reprod Date: 2013-02-18 Impact factor: 4.025