Literature DB >> 20934362

Swift Acetate Glial Assay (SAGA): an accelerated human ¹³C MRS brain exam for clinical diagnostic use.

Napapon Sailasuta1, Thao T Tran, Kent C Harris, B D Ross.   

Abstract

We demonstrate a robust procedure for the quantitative characterization of glial metabolism in human brain. In the past, the slope of the uptake and production of enriched label at steady state were used to determine metabolic rates, requiring the patient to be in the magnet for 120-160 min. In the present method, (13)C cerebral metabolite profiles were acquired at steady state alone on a routine clinical MR scanner in 25.6 min. Results obtained from the new short method (SAGA) were comparable to those achieved in a conventional, long method and effective for determination of glial metabolic rate in posterior-parietal and frontal brain regions.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20934362      PMCID： PMC2993807          DOI： 10.1016/j.jmr.2010.09.010

Source DB:  PubMed          Journal:  J Magn Reson        ISSN： 1090-7807            Impact factor:   2.229


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