BACKGROUND: Several studies have found a reduction in hippocampal volume in borderline personality disorder (BPD) patients. METHODS: In order to investigate the degree to which comorbid posttraumatic stress disorder (PTSD) could account for reduction in hippocampal volume in these patients, we conducted a systematic review and meta-analysis of studies that compared hippocampal volume in BPD patients with and without PTSD relative to healthy controls. RESULTS: Seven articles, involving 124 patients and 147 controls, were included. We found a statistically significant reduction for the left and right hippocampus. Data from the four studies that discriminated BPD patients with and without PTSD indicate that hippocampal volumes were reduced bilaterally in BPD patients with PTSD, relative to healthy controls, but that results were mixed for BPD patients without PTSD, relative to healthy controls. CONCLUSIONS: Results from this meta-analysis suggest that hippocampal volumes are reduced in patients with BPD, relative to healthy controls, but particularly in cases in which patients are diagnosed with comorbid PTSD.
BACKGROUND: Several studies have found a reduction in hippocampal volume in borderline personality disorder (BPD) patients. METHODS: In order to investigate the degree to which comorbid posttraumatic stress disorder (PTSD) could account for reduction in hippocampal volume in these patients, we conducted a systematic review and meta-analysis of studies that compared hippocampal volume in BPD patients with and without PTSD relative to healthy controls. RESULTS: Seven articles, involving 124 patients and 147 controls, were included. We found a statistically significant reduction for the left and right hippocampus. Data from the four studies that discriminated BPD patients with and without PTSD indicate that hippocampal volumes were reduced bilaterally in BPD patients with PTSD, relative to healthy controls, but that results were mixed for BPD patients without PTSD, relative to healthy controls. CONCLUSIONS: Results from this meta-analysis suggest that hippocampal volumes are reduced in patients with BPD, relative to healthy controls, but particularly in cases in which patients are diagnosed with comorbid PTSD.
Authors: David A A Baranger; Lauren R Few; Daniel H Sheinbein; Arpana Agrawal; Thomas F Oltmanns; Annchen R Knodt; Deanna M Barch; Ahmad R Hariri; Ryan Bogdan Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2020-02-24
Authors: Inga Niedtfeld; Lars Schulze; Annegret Krause-Utz; Traute Demirakca; Martin Bohus; Christian Schmahl Journal: PLoS One Date: 2013-06-12 Impact factor: 3.240
Authors: Kirsten Labudda; Stefan Kreisel; Thomas Beblo; Markus Mertens; Oleg Kurlandchikov; Christian G Bien; Martin Driessen; Friedrich G Woermann Journal: PLoS One Date: 2013-12-18 Impact factor: 3.240