BACKGROUND: Low birth weight conveys a modest risk for schizophrenia. The effects of high birth weight and deviant birth length are less clear. METHODS: We linked perinatal data from 10,934 subjects from the Northern Finland 1966 Birth Cohort (n = 12 058) to the Finnish Hospital Discharge Register where we identified 111 cases of DSM-III-R schizophrenia up to age 35 years. Adjusted odds ratios between the risk of schizophrenia and birth weight, birth length and ponderal index and the risk of schizophrenia were analyzed. RESULTS: Both low (OR 2.5; 95% CI 1.2-5.1) and high birth weight (OR 2.4; 95% CI 1.1-4.9) increased the risk of later schizophrenia. In addition, short (OR 2.6; 95% CI 1.1-5.9) and long babies had an elevated risk of schizophrenia as adults (OR 1.8; 95% CI 1.0-3.5). A reverse J-shape curve described the associations between birth weight, length and schizophrenia. CONCLUSIONS: Deviant intrauterine growth of the fetus in either direction was associated with increased risk of schizophrenia.
BACKGROUND: Low birth weight conveys a modest risk for schizophrenia. The effects of high birth weight and deviant birth length are less clear. METHODS: We linked perinatal data from 10,934 subjects from the Northern Finland 1966 Birth Cohort (n = 12 058) to the Finnish Hospital Discharge Register where we identified 111 cases of DSM-III-R schizophrenia up to age 35 years. Adjusted odds ratios between the risk of schizophrenia and birth weight, birth length and ponderal index and the risk of schizophrenia were analyzed. RESULTS: Both low (OR 2.5; 95% CI 1.2-5.1) and high birth weight (OR 2.4; 95% CI 1.1-4.9) increased the risk of later schizophrenia. In addition, short (OR 2.6; 95% CI 1.1-5.9) and long babies had an elevated risk of schizophrenia as adults (OR 1.8; 95% CI 1.0-3.5). A reverse J-shape curve described the associations between birth weight, length and schizophrenia. CONCLUSIONS: Deviant intrauterine growth of the fetus in either direction was associated with increased risk of schizophrenia.
Authors: Brian Miller; Jaana Suvisaari; Jouko Miettunen; Marjo-Riitta Järvelin; Jari Haukka; Antti Tanskanen; Jouko Lönnqvist; Matti Isohanni; Brian Kirkpatrick Journal: Schizophr Res Date: 2011-09-19 Impact factor: 4.939
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Authors: Jaana M Suvisaari; Virpi Taxell-Lassas; Maiju Pankakoski; Jari K Haukka; Jouko K Lönnqvist; Laura T Häkkinen Journal: Schizophr Bull Date: 2012-09-20 Impact factor: 9.306
Authors: M Delnord; K Szamotulska; A D Hindori-Mohangoo; B Blondel; A J Macfarlane; N Dattani; C Barona; S Berrut; I Zile; R Wood; L Sakkeus; M Gissler; J Zeitlin Journal: Eur J Public Health Date: 2016-01-10 Impact factor: 3.367
Authors: Åsa Magnusson; Hannele Laivuori; Anne Loft; Nan B Oldereid; Anja Pinborg; Max Petzold; Liv Bente Romundstad; Viveca Söderström-Anttila; Christina Bergh Journal: Front Pediatr Date: 2021-06-23 Impact factor: 3.418