Literature DB >> 20933128

Epigenetic alterations as cancer diagnostic, prognostic, and predictive biomarkers.

Dajun Deng1, Zhaojun Liu, Yantao Du.   

Abstract

Alterations of DNA methylation and transcription of microRNAs (miRNAs) are very stable phenomena in tissues and body fluids and suitable for sensitive detection. These advantages enable us to translate some important discoveries on epigenetic oncology into biomarkers for control of cancer. A few promising epigenetic biomarkers are emerging. Clinical trials using methylated CpG islands of p16, Septin9, and MGMT as biomarkers are carried out for predication of cancer development, diagnosis, and chemosensitivity. Circulating miRNAs are promising biomarkers, too. Breakthroughs in the past decade imply that epigenetic biomarkers may be useful in reducing the burden of cancer.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20933128     DOI： 10.1016/B978-0-12-380864-6.00005-5

Source DB:  PubMed          Journal:  Adv Genet        ISSN： 0065-2660            Impact factor:   1.944


  34 in total

1.  Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer.

Authors:  Wan-Ru Ma; Peng Xu; Zhao-Jun Liu; Jing Zhou; Lian-Kun Gu; Jun Zhang; Da-Jun Deng
Journal:  World J Gastroenterol       Date:  2020-01-14       Impact factor: 5.742

Review 2.  DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer.

Authors:  Yuji Toiyama; Yoshinaga Okugawa; Ajay Goel
Journal:  Biochem Biophys Res Commun       Date:  2014-08-13       Impact factor: 3.575

Review 3.  DNA methylation profiles in cancer diagnosis and therapeutics.

Authors:  Yunbao Pan; Guohong Liu; Fuling Zhou; Bojin Su; Yirong Li
Journal:  Clin Exp Med       Date:  2017-07-27       Impact factor: 3.984

4.  Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer.

Authors:  S H Song; M S Jeon; J W Nam; J K Kang; Y J Lee; J Y Kang; H P Kim; S W Han; G H Kang; T Y Kim
Journal:  Oncogene       Date:  2017-11-06       Impact factor: 9.867

5.  Prognostic value of the DNMTs mRNA expression and genetic polymorphisms on the clinical outcome in oral cancer patients.

Authors:  Gordana Supic; Ruzica Kozomara; Katarina Zeljic; Nebojsa Jovic; Zvonko Magic
Journal:  Clin Oral Investig       Date:  2016-03-11       Impact factor: 3.573

6.  Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production.

Authors:  Tingting Wang; Man Chen; Lian Liu; Huaiyan Cheng; You-E Yan; Ying-Hong Feng; Hui Wang
Journal:  Toxicol Appl Pharmacol       Date:  2011-09-24       Impact factor: 4.219

7.  Potential of soluble CD26 as a serum marker for colorectal cancer detection.

Authors:  Oscar J Cordero; Monica Imbernon; Loretta De Chiara; Vicenta S Martinez-Zorzano; Daniel Ayude; Maria Paez de la Cadena; F Javier Rodriguez-Berrocal
Journal:  World J Clin Oncol       Date:  2011-06-10

Review 8.  Epigenetic aberrations during oncogenesis.

Authors:  Maria Hatziapostolou; Dimitrios Iliopoulos
Journal:  Cell Mol Life Sci       Date:  2011-01-20       Impact factor: 9.261

9.  Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis.

Authors:  Zhaojun Liu; Jun Zhang; Yanhong Gao; Lirong Pei; Jing Zhou; Liankun Gu; Lianhai Zhang; Budong Zhu; Naoko Hattori; Jiafu Ji; Yasuhito Yuasa; Wooho Kim; Toshikazu Ushijima; Huidong Shi; Dajun Deng
Journal:  Clin Cancer Res       Date:  2014-07-09       Impact factor: 12.531

10.  p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells.

Authors:  Bo Wang; Dongping Li; Olga Kovalchuk
Journal:  Cell Cycle       Date:  2013-06-06       Impact factor: 4.534
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