Literature DB >> 2093310

Synthesis and absolute configurations of the cytotoxic polyacetylenes isolated from the callus of Panax ginseng.

Y Fujimoto1, M Satoh, N Takeuchi, M Kirisawa.   

Abstract

Panaxacol (1) and dihydropanaxacol (2), cytotoxic polyacetylenes isolated from the callus of Panax ginseng, were synthesized starting from D-(-)-diethyl tartrate. The absolute configuration of 1 was determined to be 9R, 10R and the absolute configuration at C-3 of 2 was tentatively assigned as 3S by the application of the R(+)-alpha-methoxy-alpha-(trifluoro methyl)phenylacetyl (MTPA) method.

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Year:  1990        PMID： 2093310     DOI： 10.1248/cpb.38.1447

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

1.  Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecules.

Authors:  Arun K Ghosh; Elena S Koltun; Geoffrey Bilcer
Journal:  Synthesis (Stuttg)       Date:  2001       Impact factor: 3.157

Review 2.  Bioactive C17 and C18 Acetylenic Oxylipins from Terrestrial Plants as Potential Lead Compounds for Anticancer Drug Development.

Authors:  Lars Porskjær Christensen
Journal:  Molecules       Date:  2020-05-31       Impact factor: 4.411

3.  Inducing Intermediates in Biotransformation of Natural Polyacetylene and A Novel Spiro-γ-Lactone from Red Ginseng by Solid Co-Culture of Two Gut Chaetomium globosum and The Potential Bioactivity Modification by Oxidative Metabolism.

Authors:  Bang-Yan Wang; Chen-Hao Zhu; Xue-Qiong Yang; Ming Hu; Ting-Ting Xu; Xue-Yin Wang; Shuang Yang; Ya-Bin Yang; Zhong-Tao Ding
Journal:  Molecules       Date:  2020-03-08       Impact factor: 4.411
  3 in total

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