Literature DB >> 20933058

Anti-neuroinflammation effect of ginsenoside Rbl in a rat model of Alzheimer disease.

Yulin Wang1, Jing Liu, Zhongmin Zhang, Pengxiang Bi, Zhiguo Qi, Chaodong Zhang.   

Abstract

The present work explored the anti-neuroinflammation effects of Ginseng Rb1 in a rat model of Alzheimer disease produced by ventricle injection of Aβ1-42. Aβ1-42 injection induces loss of learning and memory behavior of rats in Morris water maze, which could be reversed with Rb1 treatment. Further, Rb1 reversed the changes in several direct or indirect neuroinflammation markers in the hippocampus, suggesting that this could be a potential underlying mechanism and a way to develop anti-aging drugs.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20933058     DOI： 10.1016/j.neulet.2010.09.076

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  33 in total

1.  Microglial inhibitory effect of ginseng ameliorates cognitive deficits and neuroinflammation following traumatic head injury in rats.

Authors:  Anil Kumar; Puneet Rinwa; Hitesh Dhar
Journal:  Inflammopharmacology       Date:  2013-09-20       Impact factor: 4.473

Review 2.  The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review.

Authors:  Bolanle M Famakin
Journal:  Aging Dis       Date:  2014-10-01       Impact factor: 6.745

3.  Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.

Authors:  Mustafa T Ardah; Katerina E Paleologou; Guohua Lv; Sindhu A Menon; Salema B Abul Khair; Jia-Hong Lu; Bared Safieh-Garabedian; Abdulmonem A Al-Hayani; David Eliezer; Min Li; Omar M A El-Agnaf
Journal:  Neurobiol Dis       Date:  2014-11-15       Impact factor: 5.996

4.  Progressive and unconventional pharmacotherapeutic approaches to Alzheimer's disease therapy.

Authors:  Stuart Maudsley; Wayne Chadwick
Journal:  Curr Alzheimer Res       Date:  2012-01       Impact factor: 3.498

5.  Involvement of Connexin40 in the Protective Effects of Ginsenoside Rb1 Against Traumatic Brain Injury.

Authors:  Wei Chen; Yijun Guo; Wenjin Yang; Ping Zheng; Jinsong Zeng; Wusong Tong
Journal:  Cell Mol Neurobiol       Date:  2015-12-08       Impact factor: 5.046

6.  Stuck at the bench: Potential natural neuroprotective compounds for concussion.

Authors:  Anthony L Petraglia; Ethan A Winkler; Julian E Bailes
Journal:  Surg Neurol Int       Date:  2011-10-12

7.  Effects of Panax ginseng in Neurodegenerative Diseases.

Authors:  Ik-Hyun Cho
Journal:  J Ginseng Res       Date:  2012-10       Impact factor: 6.060

8.  Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer's disease experimental models.

Authors:  Joonki Kim; Sung Hun Kim; Deuk-Sik Lee; Dong-Jin Lee; Soo-Hyun Kim; Sungkwon Chung; Hyun Ok Yang
Journal:  J Ginseng Res       Date:  2013-03       Impact factor: 6.060

9.  A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system.

Authors:  Hee Jin Kim; Pitna Kim; Chan Young Shin
Journal:  J Ginseng Res       Date:  2013-03       Impact factor: 6.060

Review 10.  Modeling Alzheimer's disease with non-transgenic rat models.

Authors:  Laurent Lecanu; Vassilios Papadopoulos
Journal:  Alzheimers Res Ther       Date:  2013-05-01       Impact factor: 6.982
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.