| Literature DB >> 20932746 |
Andrew Potter1, Victoria Oldfield, Claire Nunns, Christophe Fromont, Stuart Ray, Christopher J Northfield, Christopher J Bryant, Simon F Scrace, David Robinson, Natalia Matossova, Lisa Baker, Pawel Dokurno, Allan E Surgenor, Ben Davis, Christine M Richardson, James B Murray, Jonathan D Moore.
Abstract
Pin1 is an emerging oncology target strongly implicated in Ras and ErbB2-mediated tumourigenesis. Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling. Here we report a novel series of Pin1 inhibitors based on a phenyl imidazole acid core that contains sub-μM inhibitors. Compounds have been identified that block prostate cancer cell growth under conditions where Pin1 is essential.Entities:
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Year: 2010 PMID： 20932746 DOI： 10.1016/j.bmcl.2010.09.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823