Literature DB >> 20932744

Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives.

Koneni V Sashidhara1, Abdhesh Kumar, Manoj Kumar, Anuj Srivastava, Anju Puri.   

Abstract

A series of novel coumarin bisindole heterocycles were synthesized following an uncommon method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 12 compounds tested, the compound 5e showed potent antihyperlipidemic activity and was found to decrease the plasma triglyceride levels (TG) by 55%, total cholesterol (TC) by 20%, accompanied by an increase in HDL-C/TC ratio by 42% in hyperlipidemic rats to a greater degree than some of the reference statins.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20932744     DOI： 10.1016/j.bmcl.2010.09.055

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands.

Authors:  Jan Martin; Přemysl Mladěnka; Luciano Saso; Irena Kostova
Journal:  Redox Rep       Date:  2016-02-18       Impact factor: 4.412

2.  Antibacterial and antioxidant assay of novel heteroaryl-substituted methane derivatives synthesized via ceric ammonium nitrate (CAN) catalyzed one-pot green approach.

Authors:  Monika Verma; Ajay Thakur; Shikha Kapil; Renu Sharma; Ajay Sharma; Ruchi Bharti
Journal:  Mol Divers       Date:  2022-07-03       Impact factor: 2.943

3.  Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.

Authors:  Sandip B Bharate; Jaideep B Bharate; Shabana I Khan; Babu L Tekwani; Melissa R Jacob; Ramesh Mudududdla; Rammohan R Yadav; Baljinder Singh; P R Sharma; Sudip Maity; Baldev Singh; Ikhlas A Khan; Ram A Vishwakarma
Journal:  Eur J Med Chem       Date:  2013-02-28       Impact factor: 6.514

4.  Antinociceptive properties of new coumarin derivatives bearing substituted 3,4-dihydro-2H-benzothiazines.

Authors:  Masoumeh Alipour; Mehdi Khoobi; Saeed Emami; Saeed Fallah-Benakohal; Seyedeh Farnaz Ghasemi-Niri; Mohammad Abdollahi; Alireza Foroumadi; Abbas Shafiee
Journal:  Daru       Date:  2014-01-07       Impact factor: 3.117

5.  Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches.

Authors:  Muhammad Tahir Aqeel; Nisar Ur-Rahman; Arif-Ullah Khan; Zaman Ashraf; Muhammad Latif; Hummera Rafique; Usman Rasheed
Journal:  Drug Des Devel Ther       Date:  2018-08-09       Impact factor: 4.162

Review 6.  Chalcone Derivatives: Promising Starting Points for Drug Design.

Authors:  Marcelo N Gomes; Eugene N Muratov; Maristela Pereira; Josana C Peixoto; Lucimar P Rosseto; Pedro V L Cravo; Carolina H Andrade; Bruno J Neves
Journal:  Molecules       Date:  2017-07-25       Impact factor: 4.411

7.  Passiflora edulis seed oil from west Cameroon: Chemical characterization and assessment of its hypolipidemic effect in high-fat diet-induced rats.

Authors:  Prosper Ngakou Takam; Fabrice Tonfack Djikeng; Dieudonné Kuate; Anne Pascale Nouemsi Kengne; Hermine Doungué Tsafack; Inelle Makamwé; Julius Enyong Oben
Journal:  Food Sci Nutr       Date:  2019-10-22       Impact factor: 2.863

8.  Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation.

Authors:  Victor Kartsev; Athina Geronikaki; Silvia Bua; Alessio Nocentini; Anthi Petrou; Boris Lichitsky; Mykhaylo Frasinyuk; Janis Leitans; Andris Kazaks; Kaspars Tars; Claudiu T Supuran
Journal:  Molecules       Date:  2019-10-04       Impact factor: 4.411

Review 9.  Promising Lead Compounds in the Development of Potential Clinical Drug Candidate for Drug-Resistant Tuberculosis.

Authors:  Saad Alghamdi; Shaheed Ur Rehman; Nashwa Talaat Shesha; Hani Faidah; Muhammad Khurram; Sabi Ur Rehman
Journal:  Molecules       Date:  2020-12-02       Impact factor: 4.411

10.  Triazole-diindolylmethane conjugates as new antitubercular agents: synthesis, bioevaluation, and molecular docking.

Authors:  Ashruba B Danne; Amit S Choudhari; Shakti Chakraborty; Dhiman Sarkar; Vijay M Khedkar; Bapurao B Shingate
Journal:  Medchemcomm       Date:  2018-04-11       Impact factor: 3.597
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