BACKGROUND: Diabetic cardiomyopathy has been characterized by an early impairment of left ventricular (LV) longitudinal function as opposed to preserved LV radial function. METHODS: Conventional echocardiography and longitudinal (ε(L)) and radial (ε(R)) systolic strain assessed by speckle-tracking imaging were obtained in 114 type 2 diabetic patients and 88 age-matched controls. RESULTS: LV ejection fraction was similar in diabetic patients and controls. The presence of subclinical LV systolic dysfunction in diabetic patients was demonstrated by lower values of midwall fractional shortening (18% ± 3% vs 20% ± 3%, P = .006), ε(L) (-19% ± 3% vs -22% ± 2%, P < .001), and ε(R) (50% ± 16% vs 56% ± 12%, P = .003) compared with controls. On multivariate analysis, factors predicting strain values were diabetes (P = .001) and gender (P = .001) for ε(L) and diabetes (P = .003) for ε(R). CONCLUSION: Diabetic patients without overt heart disease display subclinical alteration of both radial and longitudinal LV systolic function even after adjustment for blood pressure, age, and body mass index.
BACKGROUND:Diabetic cardiomyopathy has been characterized by an early impairment of left ventricular (LV) longitudinal function as opposed to preserved LV radial function. METHODS: Conventional echocardiography and longitudinal (ε(L)) and radial (ε(R)) systolic strain assessed by speckle-tracking imaging were obtained in 114 type 2 diabeticpatients and 88 age-matched controls. RESULTS: LV ejection fraction was similar in diabeticpatients and controls. The presence of subclinical LV systolic dysfunction in diabeticpatients was demonstrated by lower values of midwall fractional shortening (18% ± 3% vs 20% ± 3%, P = .006), ε(L) (-19% ± 3% vs -22% ± 2%, P < .001), and ε(R) (50% ± 16% vs 56% ± 12%, P = .003) compared with controls. On multivariate analysis, factors predicting strain values were diabetes (P = .001) and gender (P = .001) for ε(L) and diabetes (P = .003) for ε(R). CONCLUSION:Diabeticpatients without overt heart disease display subclinical alteration of both radial and longitudinal LV systolic function even after adjustment for blood pressure, age, and body mass index.
Authors: Giovanni Cioffi; Giorgio Faganello; Stefania De Feo; Nicola Berlinghieri; Luigi Tarantini; Andrea Di Lenarda; Bruno Pinamonti; Riccardo Candido; Pompilio Faggiano Journal: Exp Clin Cardiol Date: 2013
Authors: Danielle L Shepherd; Cody E Nichols; Tara L Croston; Sarah L McLaughlin; Ashley B Petrone; Sara E Lewis; Dharendra Thapa; Dustin M Long; Gregory M Dick; John M Hollander Journal: J Mol Cell Cardiol Date: 2015-12-03 Impact factor: 5.000