| Literature DB >> 20932009 |
Kevin G Liu1, Albert J Robichaud, Ronald C Bernotas, Yinfa Yan, Jennifer R Lo, Mei-Yi Zhang, Zoe A Hughes, Christine Huselton, Guo Ming Zhang, Jean Y Zhang, Dianne M Kowal, Deborah L Smith, Lee E Schechter, Thomas A Comery.
Abstract
As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT(6) receptor in order to identify potent and selective ligands for cognitive enhancement. Herein we report the identification of a novel series of 5-piperazinyl-3-sulfonylindazoles as potent and selective 5-HT(6) antagonists. The synthesis, SAR, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.Entities:
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Year: 2010 PMID： 20932009 DOI： 10.1021/jm1007825
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446