Literature DB >> 20931142

Enhancement of antimicrobial activity by synthetic ion channel synergy.

Jason L Atkins1, Mohit B Patel, Zachary Cusumano, George W Gokel.   

Abstract

Hydraphile synthetic ion channels were found to enhance the cytotoxicity to E. coli and B. subtilis of erythromycin, kanamycin, rifampicin, and tetracycline when co-administered with the antibiotic at sublethal concentrations of channel.

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Year:  2010        PMID： 20931142     DOI： 10.1039/c0cc03138k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Acylated and alkylated benzo(crown-ethers) form ion-dependent ion channels in biological membranes.

Authors:  Willy Carrasquel-Ursulaez; Mahzad Dehghany; Corey L Jones; Vinaykumar Idikuda; Brian Lu; Jennifer M Schomaker; Baron Chanda
Journal:  Biophys J       Date:  2022-02-02       Impact factor: 4.033

Review 2.  Ion Channels and Transporters as Therapeutic Agents: From Biomolecules to Supramolecular Medicinal Chemistry.

Authors:  Giacomo Picci; Silvia Marchesan; Claudia Caltagirone
Journal:  Biomedicines       Date:  2022-04-12

3.  Synthetic ionophores as non-resistant antibiotic adjuvants.

Authors:  Mohit B Patel; Evan Garrad; Joseph W Meisel; Saeedeh Negin; Michael R Gokel; George W Gokel
Journal:  RSC Adv       Date:  2019-01-17       Impact factor: 4.036

4.  A synthetic chloride channel relaxes airway smooth muscle of the rat.

Authors:  Kwok-hei Yau; Judith Choi-wo Mak; Susan Wai-sum Leung; Dan Yang; Paul M Vanhoutte
Journal:  PLoS One       Date:  2012-09-26       Impact factor: 3.240

5.  Hydraphiles: a rigorously studied class of synthetic channel compounds with in vivo activity.

Authors:  Saeedeh Negin; Bryan A Smith; Alexandra Unger; W Matthew Leevy; George W Gokel
Journal:  Int J Biomed Imaging       Date:  2013-01-15

6.  Supramolecular approaches to combining membrane transport with adhesion.

Authors:  Simon J Webb
Journal:  Acc Chem Res       Date:  2013-05-17       Impact factor: 22.384

Review 7.  The Supramolecular Self-Assembly of Aminoglycoside Antibiotics and their Applications.

Authors:  Ratan W Jadhav; Mohammad Al Kobaisi; Lathe A Jones; Ajayan Vinu; Sheshanath V Bhosale
Journal:  ChemistryOpen       Date:  2019-08-26       Impact factor: 2.911
  7 in total

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