OBJECTIVE: To estimate the risk of congenital anomalies in offspring of women with type 1 diabetes in Norway during recent years. DESIGN: Nationwide population-based study using the Medical Birth Registry of Norway and the Norwegian type 1 Diabetes Registry. SETTING: All birth clinics in Norway. PARTICIPANTS: All births in Norway during 1999-2004 (N = 350,961), of which 1,583 were births by a mother registered with pregestational type 1 diabetes. MAIN OUTCOME MEASURE: Congenital anomalies, excluding minor anomalies according to the EUROCAT system. RESULTS: Anomalies were registered in 5.7% of offspring of women with type 1 diabetes, and in 2.9% among the background population (odds ratio 2.1, 95% CI: 1.7-2.6). Cardiovascular anomalies were registered in 3.2% in the diabetes group and 0.94% in the background population (odds ratio 3.5, 95% CI: 2.7-4.7). Results were similar when restricted to women identified with type 1 diabetes through the Diabetes Registry. CONCLUSIONS: Women in Norway with type 1 diabetes experience a significantly higher risk of congenital anomalies in their babies compared with the background population.
OBJECTIVE: To estimate the risk of congenital anomalies in offspring of women with type 1 diabetes in Norway during recent years. DESIGN: Nationwide population-based study using the Medical Birth Registry of Norway and the Norwegian type 1 Diabetes Registry. SETTING: All birth clinics in Norway. PARTICIPANTS: All births in Norway during 1999-2004 (N = 350,961), of which 1,583 were births by a mother registered with pregestational type 1 diabetes. MAIN OUTCOME MEASURE: Congenital anomalies, excluding minor anomalies according to the EUROCAT system. RESULTS:Anomalies were registered in 5.7% of offspring of women with type 1 diabetes, and in 2.9% among the background population (odds ratio 2.1, 95% CI: 1.7-2.6). Cardiovascular anomalies were registered in 3.2% in the diabetes group and 0.94% in the background population (odds ratio 3.5, 95% CI: 2.7-4.7). Results were similar when restricted to women identified with type 1 diabetes through the Diabetes Registry. CONCLUSIONS:Women in Norway with type 1 diabetes experience a significantly higher risk of congenital anomalies in their babies compared with the background population.
Authors: Anders Engeland; Tone Bjørge; Anne Kjersti Daltveit; Svetlana Skurtveit; Siri Vangen; Stein Emil Vollset; Kari Furu Journal: Br J Clin Pharmacol Date: 2013-04 Impact factor: 4.335
Authors: Yuxiao Wu; Buyun Liu; Yangbo Sun; Yang Du; Mark K Santillan; Donna A Santillan; Linda G Snetselaar; Wei Bao Journal: Diabetes Care Date: 2020-10-21 Impact factor: 19.112