Literature DB >> 20929201

A concise and convergent synthesis of PA-824.

Maurice A Marsini1, Paul J Reider, Erik J Sorensen.   

Abstract

An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.

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Year:  2010        PMID: 20929201     DOI: 10.1021/jo1015807

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  6 in total

1.  Highly Enantioselective, Hydrogen-Bond-Donor Catalyzed Additions to Oxetanes.

Authors:  Daniel A Strassfeld; Zachary K Wickens; Elias Picazo; Eric N Jacobsen
Journal:  J Am Chem Soc       Date:  2020-05-06       Impact factor: 15.419

Review 2.  Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950-2021 Comprehensive Overview.

Authors:  Ria Gupta; Sumit Sharma; Rohit Singh; Ram A Vishwakarma; Serge Mignani; Parvinder Pal Singh
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-30

Review 3.  Recent Progress in the Synthesis of Drugs and Bioactive Molecules Incorporating Nitro(het)arene Core.

Authors:  Maxim Bastrakov; Alexey Starosotnikov
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-03

4.  Thiolates chemically induce redox activation of BTZ043 and related potent nitroaromatic anti-tuberculosis agents.

Authors:  Rohit Tiwari; Garrett C Moraski; Viktor Krchňák; Patricia A Miller; Mariangelli Colon-Martinez; Eliza Herrero; Allen G Oliver; Marvin J Miller
Journal:  J Am Chem Soc       Date:  2013-02-25       Impact factor: 15.419

5.  Design and Synthesis of Molecular Scaffolds with Anti-infective Activity.

Authors:  Junjia Liu; T Aaron Bedell; Julian G West; Erik J Sorensen
Journal:  Tetrahedron       Date:  2016-01-28       Impact factor: 2.457

Review 6.  Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases.

Authors:  Hollis D Showalter
Journal:  Molecules       Date:  2020-09-10       Impact factor: 4.411

  6 in total

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