BACKGROUND: Due to increasing antimicrobial resistance there has been renewed interest in old drugs that have fallen into disuse because of toxic side effects. OBJECTIVES: To evaluate the susceptibility profile, in our hospital, of Enterobacteriaceae and Streptococcus pneumoniae isolates to chloramphenicol and to compare them with the susceptibility to amoxicillin-clavulanate. METHODS: All isolates of Enterobacteriaceae and S. pneumoniae recovered in our lab during a one year period were tested for susceptibility to chloramphenicol and amoxicillin-clavulanate or penicillin, respectively. RESULTS: Of 413 Enterobacteriaceae isolates, 182 (44.1%) were resistant to amoxicillin-clavulanate, but only 76 (18.4%) were resistant to chloramphenicol. Of 189 isolates of S. pneumoniae, 4 (2.1%) were highly resistant to penicillin and 73 (38.8%) were partially resistant, while only 2 (1.1%) were resistant to chloramphenicol. None of the 24 S. pneumoniae isolates causing invasive diseases exhibited resistance to chloramphenicol CONCLUSIONS: In an era of increasing resistance to many antibiotic preparations, chloramphenicol might have a role in the treatment of intraabdominal and respiratory tract infections.
BACKGROUND: Due to increasing antimicrobial resistance there has been renewed interest in old drugs that have fallen into disuse because of toxic side effects. OBJECTIVES: To evaluate the susceptibility profile, in our hospital, of Enterobacteriaceae and Streptococcus pneumoniae isolates to chloramphenicol and to compare them with the susceptibility to amoxicillin-clavulanate. METHODS: All isolates of Enterobacteriaceae and S. pneumoniae recovered in our lab during a one year period were tested for susceptibility to chloramphenicol and amoxicillin-clavulanate or penicillin, respectively. RESULTS: Of 413 Enterobacteriaceae isolates, 182 (44.1%) were resistant to amoxicillin-clavulanate, but only 76 (18.4%) were resistant to chloramphenicol. Of 189 isolates of S. pneumoniae, 4 (2.1%) were highly resistant to penicillin and 73 (38.8%) were partially resistant, while only 2 (1.1%) were resistant to chloramphenicol. None of the 24 S. pneumoniae isolates causing invasive diseases exhibited resistance to chloramphenicol CONCLUSIONS: In an era of increasing resistance to many antibiotic preparations, chloramphenicol might have a role in the treatment of intraabdominal and respiratory tract infections.
Authors: Paolo S Ocampo; Viktória Lázár; Balázs Papp; Markus Arnoldini; Pia Abel zur Wiesch; Róbert Busa-Fekete; Gergely Fekete; Csaba Pál; Martin Ackermann; Sebastian Bonhoeffer Journal: Antimicrob Agents Chemother Date: 2014-05-27 Impact factor: 5.191
Authors: Diane Borselli; Aurélie Lieutaud; Hélène Thefenne; Eric Garnotel; Jean-Marie Pagès; Jean Michel Brunel; Jean-Michel Bolla Journal: PLoS One Date: 2016-05-06 Impact factor: 3.240
Authors: Robin A Sorg; Leo Lin; G Sander van Doorn; Moritz Sorg; Joshua Olson; Victor Nizet; Jan-Willem Veening Journal: PLoS Biol Date: 2016-12-27 Impact factor: 8.029