Literature DB >> 20927467

A straightforward approach towards 5-substituted thiazolylpeptides via the thio-Ugi-reaction.

Uli Kazmaier1, Andrea Persch.   

Abstract

A wide range of 5-substituted thiazoles are easily accessible via cross coupling of thiazolyl triflates. These activated thiazoles can be obtained by Ugi reactions using thioacids (thio-Ugi-reaction) and subsequent cyclisation of the endo thiopeptides formed with triflic anhydride. In addition, cyclisations with acyl halides give rise to 5-acyloxysubstituted derivatives.

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Year:  2010        PMID： 20927467     DOI： 10.1039/c0ob00453g

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions.

Authors:  Ameer F Zahoor; Sarah Thies; Uli Kazmaier
Journal:  Beilstein J Org Chem       Date:  2011-09-19       Impact factor: 2.883

Review 2.  Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

Authors:  Gijs Koopmanschap; Eelco Ruijter; Romano Va Orru
Journal:  Beilstein J Org Chem       Date:  2014-03-04       Impact factor: 2.883

3.  Cysteine Isocyanide in Multicomponent Reaction: Synthesis of Peptido-Mimetic 1,3-Azoles.

Authors:  Thimmalapura M Vishwanatha; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Alexander Dömling
Journal:  J Org Chem       Date:  2017-08-25       Impact factor: 4.354

4.  Synthetic studies towards bottromycin.

Authors:  Stefanie Ackermann; Hans-Georg Lerchen; Dieter Häbich; Angelika Ullrich; Uli Kazmaier
Journal:  Beilstein J Org Chem       Date:  2012-10-01       Impact factor: 2.883
  4 in total

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