Literature DB >> 20927454

Bringing natural products into the fold - exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases.

P Matthew Joyner1, Robert H Cichewicz.   

Abstract

A review with 187 references, describing natural products that exhibit bioactive properties relevant to the treatment of protein aggregation-related neurodegenerative diseases (e.g., Huntington's, Parkinson's, and prion diseases) and comparing the chemical properties of these secondary metabolite leads to compounds in clinical use for treating central nervous system conditions.

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Year:  2010        PMID： 20927454     DOI： 10.1039/c0np00017e

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  11 in total

1.  trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.

Authors:  Jinrong Fu; Jing Jin; Robert H Cichewicz; Serena A Hageman; Trevor K Ellis; Lan Xiang; Qi Peng; Mali Jiang; Nicolas Arbez; Katelyn Hotaling; Christopher A Ross; Wenzhen Duan
Journal:  J Biol Chem       Date:  2012-05-30       Impact factor: 5.157

Review 2.  Neurotrophic natural products: chemistry and biology.

Authors:  Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-18       Impact factor: 15.336

3.  Neuroprotective effect of aqueous extract of Selaginella delicatula as evidenced by abrogation of rotenone-induced motor deficits, oxidative dysfunctions, and neurotoxicity in mice.

Authors:  Girish Chandran
Journal:  Cell Mol Neurobiol       Date:  2013-07-19       Impact factor: 5.046

4.  Dihydroartemisinin treatment of multiple myeloma cells causes activation of c-Jun leading to cell apoptosis.

Authors:  Yong Wang; Xiaoyuan Xu; Xiaojian Wu; Weibin Chen; Fangmei Huang; Xiaomin Gui
Journal:  Oncol Lett       Date:  2017-12-11       Impact factor: 2.967

Review 5.  Mechanisms and Effects Posed by Neurotoxic Products of Cyanobacteria/Microbial Eukaryotes/Dinoflagellates in Algae Blooms: a Review.

Authors:  Fiona D Mello; Nady Braidy; Helder Marçal; Gilles Guillemin; Seyed Mohammad Nabavi; Brett A Neilan
Journal:  Neurotox Res       Date:  2017-08-23       Impact factor: 3.911

6.  Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.

Authors:  Lynnie Trzoss; Jing Xu; Michelle H Lacoske; William C Mobley; Emmanuel A Theodorakis
Journal:  Chemistry       Date:  2013-03-22       Impact factor: 5.236

7.  GST-4-Dependent Suppression of Neurodegeneration in C. elegans Models of Parkinson's and Machado-Joseph Disease by Rapeseed Pomace Extract Supplementation.

Authors:  Franziska Pohl; Andreia Teixeira-Castro; Marta Daniela Costa; Victoria Lindsay; Juliana Fiúza-Fernandes; Marie Goua; Giovanna Bermano; Wendy Russell; Patrícia Maciel; Paul Kong Thoo Lin
Journal:  Front Neurosci       Date:  2019-10-17       Impact factor: 4.677

Review 8.  Natural biomolecules and protein aggregation: emerging strategies against amyloidogenesis.

Authors:  Antonella Sgarbossa
Journal:  Int J Mol Sci       Date:  2012-12-14       Impact factor: 5.923

9.  Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation.

Authors:  Lynnie Trzoss; Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Beilstein J Org Chem       Date:  2013-06-12       Impact factor: 2.883

Review 10.  Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines.

Authors:  Ying Han; Hui Sun; Aihua Zhang; Guangli Yan; Xi-Jun Wang
Journal:  Pharmacol Ther       Date:  2020-09-18       Impact factor: 12.310
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