| Literature DB >> 20926402 |
Fred R Hirsch1, Murry W Wynes, David R Gandara, Paul A Bunn.
Abstract
The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed. ©2010 AACR.Entities:
Mesh:
Year: 2010 PMID: 20926402 DOI: 10.1158/1078-0432.CCR-10-2005
Source DB: PubMed Journal: Clin Cancer Res ISSN: 1078-0432 Impact factor: 12.531