| Literature DB >> 20926331 |
Rupesh Dash1, Sujit K Bhutia, Belal Azab, Zhao-zhong Su, Bridget A Quinn, Timothy P Kegelmen, Swadesh K Das, Keetae Kim, Seok-Geun Lee, Margaret A Park, Adly Yacoub, Mohammed Rahmani, Luni Emdad, Igor P Dmitriev, Xiang-Yang Wang, Devanand Sarkar, Steven Grant, Paul Dent, David T Curiel, Paul B Fisher.
Abstract
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.Entities:
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Year: 2010 PMID： 20926331 PMCID： PMC3164830 DOI： 10.1016/j.cytogfr.2010.08.004
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638