| Literature DB >> 20926294 |
Yue H Li1, Pei-San Tseng, Karen A Evans, Jon-Paul Jaworski, Dwight M Morrow, Harvey E Fries, Charlene W Wu, Richard M Edwards, Jian Jin.
Abstract
A series of 3-urea-1-(phenylmethyl)-pyridones was discovered as novel EP(3) antagonists via high-throughput screening and subsequent optimization. The synthesis, structure-activity relationships, and optimization of the initial hit that resulted in potent and selective EP(3) receptor antagonists such as 11g are described.Entities:
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Year: 2010 PMID： 20926294 DOI： 10.1016/j.bmcl.2010.08.137
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823