OBJECTIVES: Thiazolidinediones (TZDs), including rosiglitazone and pioglitazone, are widely used as antidiabetic agents. Here we present an updated meta-analysis of the respective effects of rosiglitazone and pioglitazone on the levels of C-reactive protein (CRP), a biomarker and predictor of CAD risks. METHODS AND RESULTS: PubMed and EMBASE were systematically searched using the terms "C-reactive protein" and "rosiglitazone" or "pioglitazone" or "thiazolidinedione". A total of 59 rosiglitazone studies and 36 pioglitazone studies were included for evaluation. These were classified as 2-group studies and 1-group studies according to their study design. Standard mean difference (SMD) of CRP and 95% CI were calculated to evaluate the effect of TZDs on CRP. The overall SMD for rosiglitazone treatment is -0.392 (95% CI, [-0.446, -0.338]) in 2-group studies and -0.424 (95% CI, [-0.501, -0.346]) in 1-group studies. The overall SMD for pioglitazone treatment is -0.577 (95% CI, [-0.732, -0.421]) in 2-group studies and -0.327 (95% CI, [-0.439, -0.216]) in 1-group studies. Moreover, TZDs were found to significantly reduce CRP levels in both diabetes mellitus (DM) and non-DM patients. CONCLUSIONS: Our meta-analysis suggested that both rosiglitazone and pioglitazone significantly decrease serum CRP levels. TZDs presented their CRP-lowering effect in both DM and non-DM patients.
OBJECTIVES:Thiazolidinediones (TZDs), including rosiglitazone and pioglitazone, are widely used as antidiabetic agents. Here we present an updated meta-analysis of the respective effects of rosiglitazone and pioglitazone on the levels of C-reactive protein (CRP), a biomarker and predictor of CAD risks. METHODS AND RESULTS: PubMed and EMBASE were systematically searched using the terms "C-reactive protein" and "rosiglitazone" or "pioglitazone" or "thiazolidinedione". A total of 59 rosiglitazone studies and 36 pioglitazone studies were included for evaluation. These were classified as 2-group studies and 1-group studies according to their study design. Standard mean difference (SMD) of CRP and 95% CI were calculated to evaluate the effect of TZDs on CRP. The overall SMD for rosiglitazone treatment is -0.392 (95% CI, [-0.446, -0.338]) in 2-group studies and -0.424 (95% CI, [-0.501, -0.346]) in 1-group studies. The overall SMD for pioglitazone treatment is -0.577 (95% CI, [-0.732, -0.421]) in 2-group studies and -0.327 (95% CI, [-0.439, -0.216]) in 1-group studies. Moreover, TZDs were found to significantly reduce CRP levels in both diabetes mellitus (DM) and non-DMpatients. CONCLUSIONS: Our meta-analysis suggested that both rosiglitazone and pioglitazone significantly decrease serum CRP levels. TZDs presented their CRP-lowering effect in both DM and non-DMpatients.
Authors: Yazmín Hernández-Díaz; Carlos Alfonso Tovilla-Zárate; Isela Juárez-Rojop; María Lilia López-Narváez; José Francisco Álvarez-Cámara; Thelma Beatriz González-Castro Journal: Int J Environ Res Public Health Date: 2016-01-06 Impact factor: 3.390