| Literature DB >> 20925336 |
Qingmao Wu1, Jun Zhou, Zhigang Yao, Fan Xu, Qi Shen.
Abstract
A highly efficient method for the synthesis of α-hydroxy phosphonates via lanthanide amides [(Me(3)Si)(2)N](3)Ln(μ-Cl)Li(THF)(3) catalyzed hydrophosphonylation of aromatic aldehydes was developed. The reactions produced the products in excellent yields in the presence of 0.1 mol % [(Me(3)Si)(2)N](3)La(μ-Cl)Li(THF)(3) at room temperature within 5 min. The existence of LiCl in the catalyst was a key factor affecting the catalytic activity. The mechanism for the process of high efficiency was proposed.Entities:
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Year: 2010 PMID： 20925336 DOI： 10.1021/jo101743e
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354