S Savas Erdeve1, E Simsek, Yildiz Dallar, Zeynep Biyikli. 1. Department of Pediatrics, Division of Pediatric Endocrinology, Ankara University School of Medicine, Ulusoy 312 City No: 16 B46, Cayyolu, 06830, Ankara, Turkey. senaysavas@yahoo.com
Abstract
OBJECTIVE: To assess whether apoB/apoA1 ratio is associated or not with metabolic syndrome in obese children. METHODS: A 198 obese children and 41 healthy control subjects were enrolled in a cross-sectional study. The apoB/apoA1 ratio and other metabolic syndrome components in obese children with/without metabolic syndrome were compared to healthy controls. RESULTS: The apoA1 level did not show significant difference (p = 0.664) but apoB level (p = 0.000) and apoB/apoA1 ratio (p = 0.001) were significantly higher in obese group than in control group. Also, the apoB/apoA1 ratio was significantly higher in obese children with metabolic syndrome when compared to obese children without metabolic syndrome (p = 0.007) and showed positive correlation with triglyceride (r = 0.404, p = 0.000) and negative correlation with high-density lipoprotein cholesterol (r = -0.593, p = 0.000). CONCLUSIONS: The apoB/apoA1 ratio is associated with metabolic syndrome in obese children. An elevated apoB/apoA1 ratio may constitute an important feature of the metabolic syndrome. There is a need for long term follow-up studies concerning cardiovascular risk in obese children with metabolic syndrome and high apoB/apoA1 ratio.
OBJECTIVE: To assess whether apoB/apoA1 ratio is associated or not with metabolic syndrome in obesechildren. METHODS: A 198 obesechildren and 41 healthy control subjects were enrolled in a cross-sectional study. The apoB/apoA1 ratio and other metabolic syndrome components in obesechildren with/without metabolic syndrome were compared to healthy controls. RESULTS: The apoA1 level did not show significant difference (p = 0.664) but apoB level (p = 0.000) and apoB/apoA1 ratio (p = 0.001) were significantly higher in obese group than in control group. Also, the apoB/apoA1 ratio was significantly higher in obesechildren with metabolic syndrome when compared to obesechildren without metabolic syndrome (p = 0.007) and showed positive correlation with triglyceride (r = 0.404, p = 0.000) and negative correlation with high-density lipoprotein cholesterol (r = -0.593, p = 0.000). CONCLUSIONS: The apoB/apoA1 ratio is associated with metabolic syndrome in obesechildren. An elevated apoB/apoA1 ratio may constitute an important feature of the metabolic syndrome. There is a need for long term follow-up studies concerning cardiovascular risk in obesechildren with metabolic syndrome and high apoB/apoA1 ratio.
Authors: N Tümer; F Yalçinkaya; E Ince; M Ekim; K Köse; N Cakar; N Kara; N Ozkaya; C Ensari; S Onder Journal: Pediatr Nephrol Date: 1999-06 Impact factor: 3.714
Authors: Apoor S Gami; Brandi J Witt; Daniel E Howard; Patricia J Erwin; Lisa A Gami; Virend K Somers; Victor M Montori Journal: J Am Coll Cardiol Date: 2007-01-12 Impact factor: 24.094
Authors: Ravi Retnakaran; Bernard Zinman; Philip W Connelly; Stewart B Harris; Anthony J G Hanley Journal: J Pediatr Date: 2006-02 Impact factor: 4.406
Authors: M V Papavasileiou; A G Karamanou; P Kalogeropoulos; G Moustakas; S Patsianis; A Pittaras Journal: J Hum Hypertens Date: 2015-07-02 Impact factor: 3.012
Authors: Melissa Quintero Escobar; Tássia Brena Barroso Carneiro Costa; Lucas G Martins; Silvia S Costa; André vanHelvoort Lengert; Érica Boldrini; Sandra Regina Morini da Silva; Luiz Fernando Lopes; Daniel Onofre Vidal; Ana C V Krepischi; Mariana Maschietto; Ljubica Tasic Journal: Front Oncol Date: 2020-10-16 Impact factor: 6.244