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Literature DB >> 20923974

Cdc14-dependent dephosphorylation of a kinetochore protein prior to anaphase in Saccharomyces cerevisiae.

Abstract

The budding yeast Cdc14 phosphatase reverses Cdk1 phosphorylation to promote mitotic exit. Although Cdc14 activity is thought to be restricted to anaphase, we found that dephosphorylation of the Dsn1 kinetochore protein in metaphase requires Cdc14. These data suggest that there is a nonnucleolar pool of active Cdc14 prior to anaphase.

Entities: Gene Species

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Year: 2010 PMID： 20923974 PMCID： PMC2998326 DOI： 10.1534/genetics.110.123653

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

49 in total

1. Targets of the cyclin-dependent kinase Cdk1.

Authors: Jeffrey A Ubersax; Erika L Woodbury; Phuong N Quang; Maria Paraz; Justin D Blethrow; Kavita Shah; Kevan M Shokat; David O Morgan
Journal: Nature Date: 2003-10-23 Impact factor: 49.962

2. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex.

Authors: W Shou; J H Seol; A Shevchenko; C Baskerville; D Moazed; Z W Chen; J Jang; A Shevchenko; H Charbonneau; R J Deshaies
Journal: Cell Date: 1999-04-16 Impact factor: 41.582

3. Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae.

Authors: Ghia M Euskirchen
Journal: Eukaryot Cell Date: 2002-04

4. The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase.

Authors: Susanne Trautmann; Srividya Rajagopalan; Dannel McCollum
Journal: Dev Cell Date: 2004-11 Impact factor: 12.270

5. Oscillations in Cdc14 release and sequestration reveal a circuit underlying mitotic exit.

Authors: Romilde Manzoni; Francesca Montani; Clara Visintin; Fabrice Caudron; Andrea Ciliberto; Rosella Visintin
Journal: J Cell Biol Date: 2010-07-26 Impact factor: 10.539

6. Interactions between centromere complexes in Saccharomyces cerevisiae.

Authors: Vladimir S Nekrasov; Melanie A Smith; Sew Peak-Chew; John V Kilmartin
Journal: Mol Biol Cell Date: 2003-10-17 Impact factor: 4.138

7. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase.

Authors: Benjamin A Pinsky; Sean Y Tatsutani; Kimberly A Collins; Sue Biggins
Journal: Dev Cell Date: 2003-11 Impact factor: 12.270

8. Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis.

Authors: N Cueille; E Salimova; V Esteban; M Blanco; S Moreno; A Bueno; V Simanis
Journal: J Cell Sci Date: 2001-07 Impact factor: 5.285

9. The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly.

Authors: Stéphanie Buvelot; Sean Y Tatsutani; Danielle Vermaak; Sue Biggins
Journal: J Cell Biol Date: 2003-02-03 Impact factor: 10.539

10. Architecture of the budding yeast kinetochore reveals a conserved molecular core.

Authors: Stefan Westermann; Iain M Cheeseman; Scott Anderson; John R Yates; David G Drubin; Georjana Barnes
Journal: J Cell Biol Date: 2003-10-27 Impact factor: 10.539

12 in total

1. Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization.

Authors: Guðjón Ólafsson; Peter H Thorpe
Journal: Proc Natl Acad Sci U S A Date: 2015-08-03 Impact factor: 11.205

2. The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

Authors: Alberto Sanchez-Diaz; Pedro Junior Nkosi; Stephen Murray; Karim Labib
Journal: EMBO J Date: 2012-08-07 Impact factor: 11.598

Cdc14-dependent dephosphorylation of a kinetochore protein prior to anaphase in Saccharomyces cerevisiae.

1. Targets of the cyclin-dependent kinase Cdk1.

2. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex.

3. Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae.

4. The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase.

5. Oscillations in Cdc14 release and sequestration reveal a circuit underlying mitotic exit.

6. Interactions between centromere complexes in Saccharomyces cerevisiae.

7. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase.

8. Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis.

9. The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly.

10. Architecture of the budding yeast kinetochore reveals a conserved molecular core.

1. Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization.

2. The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

3. The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast.

Review 4. Cell-cycle phospho-regulation of the kinetochore.

Review 5. Regulation of kinetochore configuration during mitosis.

6. Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis.

7. Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity.

8. Adaptation to the spindle checkpoint is regulated by the interplay between Cdc28/Clbs and PP2ACdc55.

9. Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast.

10. The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein.