Literature DB >> 20923854

The role of asymmetric dimethylarginine and arginine in the failing heart and its vasculature.

Marlieke Visser1, Walter J Paulus, Mechteld A R Vermeulen, Milan C Richir, Mariska Davids, Willem Wisselink, Bas A J M de Mol, Paul A M van Leeuwen.   

Abstract

Nitric oxide (NO) is formed from arginine by the enzyme nitric oxide synthase (NOS). Asymmetric dimethylarginine (ADMA) can inhibit NO production by competing with arginine for NOS binding. Therefore, the net amount of NO might be indicated by the arginine/ADMA ratio. In turn, arginine can be metabolized by the enzyme arginase, and ADMA by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). While ADMA has been implicated as a cardiovascular risk factor, arginine supplementation has been indicated as a treatment in cardiac diseases. This review discusses the roles of ADMA and arginine in the failing heart and its vasculature. Furthermore, it proposes nutritional therapies to improve NO availability.

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Year:  2010        PMID： 20923854     DOI： 10.1093/eurjhf/hfq158

Source DB:  PubMed          Journal:  Eur J Heart Fail        ISSN： 1388-9842            Impact factor:   15.534


  22 in total

1.  Oxidative stress and nitric oxide pathway in adult patients who are candidates for cardiac surgery: patterns and differences.

Authors:  Viviana Cavalca; Elena Tremoli; Benedetta Porro; Fabrizio Veglia; Veronika Myasoedova; Isabella Squellerio; Daniela Manzone; Marco Zanobini; Matteo Trezzi; Matteo Nicola Dario Di Minno; José Pablo Werba; Calogero Tedesco; Francesco Alamanni; Alessandro Parolari
Journal:  Interact Cardiovasc Thorac Surg       Date:  2013-09-07

2.  Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.

Authors:  Jennifer K Trittmann; Eric Peterson; Lynette K Rogers; Bernadette Chen; Carl H Backes; Mark A Klebanoff; Leif D Nelin
Journal:  J Pediatr       Date:  2014-10-11       Impact factor: 4.406

Review 3.  Amino acids and derivatives, a new treatment of chronic heart failure?

Authors:  Valentina Carubelli; Anna Isotta Castrini; Valentina Lazzarini; Mihai Gheorghiade; Marco Metra; Carlo Lombardi
Journal:  Heart Fail Rev       Date:  2015-01       Impact factor: 4.214

4.  Arginine catabolism metabolites and atrial fibrillation or heart failure risk: 2 case-control studies within the Prevención con Dieta Mediterránea (PREDIMED) trial.

Authors:  Leticia Goni; Cristina Razquin; Estefanía Toledo; Marta Guasch-Ferré; Clary B Clish; Nancy Babio; Clemens Wittenbecher; Alessandro Atzeni; Jun Li; Liming Liang; Courtney Dennis; Ángel Alonso-Gómez; Montserrat Fitó; Dolores Corella; Enrique Gómez-Gracia; Ramón Estruch; Miquel Fiol; Jose Lapetra; Lluis Serra-Majem; Emilio Ros; Fernando Arós; Jordi Salas-Salvadó; Frank B Hu; Miguel A Martínez-González; Miguel Ruiz-Canela
Journal:  Am J Clin Nutr       Date:  2022-09-02       Impact factor: 8.472

5.  Protective effect of CDP-choline on ischemia-reperfusion-induced myocardial tissue injury in rats.

Authors:  C Coskun; B Avci; M Yalcin; A Yermezler; M S Yilmaz; V Savci
Journal:  Ir J Med Sci       Date:  2013-11-29       Impact factor: 1.568

Review 6.  Liver plays a central role in asymmetric dimethylarginine-mediated organ injury.

Authors:  Andrea Ferrigno; Laura G Di Pasqua; Clarissa Berardo; Plinio Richelmi; Mariapia Vairetti
Journal:  World J Gastroenterol       Date:  2015-05-07       Impact factor: 5.742

7.  Asymmetrical dimethylarginine--more sensitive than NT-proBNP to diagnose heart failure in adults with congenital heart disease.

Authors:  Oktay Tutarel; Agnieszka Denecke; Stefanie M Bode-Böger; Jens Martens-Lobenhoffer; Svjetlana Lovric; Johann Bauersachs; Bernhard Schieffer; Mechthild Westhoff-Bleck; Jan T Kielstein
Journal:  PLoS One       Date:  2012-03-21       Impact factor: 3.240

8.  Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting.

Authors:  Marlieke Visser; Mariska Davids; Hein J Verberne; Wouter E M Kok; Hans W M Niessen; Lenny M W van Venrooij; Riccardo Cocchieri; Willem Wisselink; Bas A J M de Mol; Paul A M van Leeuwen
Journal:  J Cardiothorac Surg       Date:  2011-03-25       Impact factor: 1.637

Review 9.  Nitric oxide synthases in heart failure.

Authors:  Ricardo Carnicer; Mark J Crabtree; Vidhya Sivakumaran; Barbara Casadei; David A Kass
Journal:  Antioxid Redox Signal       Date:  2012-09-20       Impact factor: 8.401

10.  Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.

Authors:  Inderjit Singh; Judong Kim; Nishant Saxena; Seungho Choi; S M Touhidul Islam; Avtar K Singh; Mushfiquddin Khan; Jeseong Won
Journal:  Immunology       Date:  2021-08-02       Impact factor: 7.397
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