Literature DB >> 20923259

Anastrozole.

Catherine M Kelly1, Aman U Buzdar.   

Abstract

IMPORTANCE OF THE FIELD: Anastrozole is a third-generation aromatase inhibitor used in the adjuvant setting for the treatment of hormone receptor-positive breast cancer. Several adjuvant randomized trials have reported greater efficacy for anastrozole when compared to tamoxifen. AREAS COVERED IN THIS REVIEW: This review discusses the mechanism of action of anastrozole; pharmacokinetic and pharmacodynamic characteristics; results of randomized controlled trials of anastrozole compared to tamoxifen in the adjuvant treatment of postmenopausal women with hormone receptor-positive breast cancer and the safety profile of anastrozole compared to tamoxifen. WHAT THE READER WILL GAIN: The reader will gain an understanding of the basic pharmacology of anastrozole, efficacy data from clinical trials comparing anastrozole to tamoxifen, safety profile of anastrozole and ongoing areas of research. TAKE HOME MESSAGE: The adverse effects of anastrozole.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20923259     DOI： 10.1517/14740338.2010.515977

Source DB:  PubMed          Journal:  Expert Opin Drug Saf        ISSN： 1474-0338            Impact factor:   4.250


  7 in total

1.  Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation.

Authors:  Ralf Regenthal; Margarita Voskanian; Frank Baumann; Jens Teichert; Christian Brätter; Achim Aigner; Getu Abraham
Journal:  Drug Des Devel Ther       Date:  2018-11-01       Impact factor: 4.162

2.  The efficacy of anastrozole in subfertile men with and without abnormal testosterone to estradiol ratios.

Authors:  Yang Yang; Shuyun Chen; Hong Chen; Yi Guo; Xiaoming Teng
Journal:  Transl Androl Urol       Date:  2022-09

Review 3.  Aromatase Inhibitors-Induced Musculoskeletal Disorders: Current Knowledge on Clinical and Molecular Aspects.

Authors:  Sara Tenti; Pierpaolo Correale; Sara Cheleschi; Antonella Fioravanti; Luigi Pirtoli
Journal:  Int J Mol Sci       Date:  2020-08-06       Impact factor: 5.923

4.  Effects of psoralen on the pharmacokinetics of anastrozole in rats.

Authors:  Yuzhu Zhang; Jingjing Wu; Yue Zhou; Yulian Yin; Hongfeng Chen
Journal:  Pharm Biol       Date:  2018-12       Impact factor: 3.503

5.  Effects of anastrozole on Ki-67 antigen expression in the vaginal epithelium of female rats in persistent estrus.

Authors:  Diego Cipriano Chagas; Maria da Conceição Barros-Oliveira; Pedro Vitor Lopes-Costa; Renato de Oliveira Pereira; Mariella de Almeida Melo; Danylo Rafhael Costa-Silva; Carine Soares Borges; Jackeline Lopes Viana; Alesse Ribeiro Dos Santos; Gil Facina; Benedito Borges da Silva
Journal:  Clinics (Sao Paulo)       Date:  2020-04-03       Impact factor: 2.365

Review 6.  Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target.

Authors:  Jessica Caciolla; Alessandra Bisi; Federica Belluti; Angela Rampa; Silvia Gobbi
Journal:  Molecules       Date:  2020-11-16       Impact factor: 4.411

7.  Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models.

Authors:  Beata Filip-Psurska; Mateusz Psurski; Artur Anisiewicz; Patrycja Libako; Ewa Zbrojewicz; Magdalena Maciejewska; Michał Chodyński; Andrzej Kutner; Joanna Wietrzyk
Journal:  Int J Mol Sci       Date:  2021-03-09       Impact factor: 5.923
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.